Lambert-Eaton Myasthenic Syndrome (LEMS) is a rare autoimmune disorder characterized by muscle weakness and fatigue due to the body’s immune system mistakenly attacking the voltage-gated calcium channels at the neuromuscular junction. This leads to impaired communication between nerves and muscles, often resulting in weakness primarily in the proximal muscles, such as those of the hips and shoulders. LEMS is frequently associated with certain cancers, particularly small cell lung cancer, making its diagnosis and management crucial for both addressing the autoimmune aspects and identifying any underlying malignancies. Treatment options may include medications that enhance neurotransmitter release, immunotherapy, and supportive therapies. Understanding LEMS is essential for effective management, improving patient outcomes and quality of life.
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