Leprosy, also known as Hansen's disease, is a chronic infectious condition caused by the bacterium Mycobacterium leprae. This disease primarily affects the skin, peripheral nerves, mucosal membranes, and eyes, leading to symptoms such as skin lesions, numbness, and muscle weakness. While leprosy is often associated with historical stigma, it is a treatable condition that has largely been managed through the use of multidrug therapy (MDT). This approach typically includes a combination of antibiotics, such as rifampicin, dapsone, and clofazimine, which effectively kill the bacteria and prevent disease progression. Early diagnosis and treatment are crucial to prevent complications and disabilities associated with the disease. Understanding leprosy and its treatment options is vital for reducing stigma, improving patient outcomes, and promoting awareness of this manageable yet historically significant condition.