Information about Purinethol (Mercaptopurine)
Purinethol (Mercaptopurine) is an oral chemotherapy medication used to treat certain types of cancer and autoimmune conditions. It is an immunosuppressive drug that works by interfering with the production of DNA and RNA, ultimately preventing the rapid growth of cancerous cells or abnormal immune responses. Mercaptopurine is commonly prescribed for conditions like leukemia and inflammatory bowel disease (IBD).
Product Highlights
- It is part of chemotherapy regimens to treat ALL, particularly in children and adults.
- It is used for conditions like Crohn’s disease and ulcerative colitis, where it helps to suppress the immune response that causes inflammation in the intestines.
- In some cases, it may be prescribed off-label to treat other autoimmune conditions.
Key Ingredient
Key Benefits
- Purinethol plays a crucial role in chemotherapy regimens for treating acute lymphoblastic leukemia (ALL), significantly improving survival rates.
- In autoimmune diseases like Crohn's disease, it helps control inflammation by suppressing overactive immune responses.
- It provides a convenient alternative to injectable chemotherapy, which can be easier for patients to manage.
Direction of Use
- Purinethol is typically taken once or twice a day, with or without food, as prescribed by a healthcare provider.
- The dosage is individualized based on the condition being treated, the patient’s weight, and their response to the medication.
- Tablets should be swallowed whole and not crushed or chewed to prevent irritation of the mouth or throat.
- Regular blood tests are required to monitor liver function and blood cell counts, as Mercaptopurine can cause side effects like liver toxicity and bone marrow suppression.
Safety Concerns
- Mercaptopurine can cause liver damage, so liver function tests should be conducted regularly during treatment.
- It may cause a decrease in blood cells, leading to increased risk of infections, anemia, and bleeding.
- As an immunosuppressive drug, Purinethol can increase the risk of infections, especially during cancer treatment or in autoimmune disorders.
- Nausea, vomiting, loss of appetite, and fatigue are common side effects. More severe effects can include pancreatitis, gastrointestinal issues, and changes in blood cell counts.
- Mercaptopurine can interact with other medications, including allopurinol (used to treat gout), which may increase the risk of side effects.
Avoid Purinethol (Mercaptopurine) If
- Patients who are allergic to mercaptopurine or any other ingredients in Purinethol should avoid using this medication.
- Mercaptopurine is contraindicated in patients with severe liver impairment, as it may exacerbate liver dysfunction.
- Since Purinethol suppresses the immune system, it should be avoided in patients with active infections or a history of recurrent infections unless specifically directed by a healthcare provider.
- Mercaptopurine is classified as a Category D drug (potential risk to the fetus), so it should generally be avoided during pregnancy unless the benefits outweigh the risks. Women should avoid becoming pregnant while taking this medication.
- It is not recommended to breastfeed while using Mercaptopurine, as it can pass into breast milk and may harm the infant.
