Information about Sancuso (Granisetron)
Sancuso is a transdermal patch that contains the active ingredient granisetron, which is a selective 5-HT3 receptor antagonist. It is used to prevent nausea and vomiting associated with chemotherapy treatments. Granisetron works by blocking serotonin receptors in the gastrointestinal tract and brain, preventing the triggers that cause nausea and vomiting. The patch form provides a continuous release of the medication over several days, offering long-lasting relief.
Product Highlights
- Sancuso is delivered through a skin patch, allowing for continuous drug release over a period of up to 7 days, providing convenience and consistent symptom control.
- The patch is specifically indicated for the prevention of nausea and vomiting associated with chemotherapy, which can significantly improve the patient's quality of life during cancer treatment.
- The transdermal delivery system is ideal for patients who may have difficulty swallowing pills or who require a more consistent, longer-acting form of medication.
Primary Indications for Sancuso (Granisetron)
- Sancuso is primarily prescribed to prevent nausea and vomiting caused by chemotherapy. It is most commonly used in patients undergoing highly emetogenic chemotherapy treatments, which have a high risk of inducing these symptoms.
- While the primary indication is chemotherapy-induced nausea and vomiting, Sancuso may be used off-label in some cases to manage nausea from other causes, as directed by a healthcare provider.
Key Ingredient
Key Benefits
- Sancuso effectively prevents nausea and vomiting associated with chemotherapy, which can improve patient comfort and compliance with cancer treatment.
- The transdermal patch delivers a steady, continuous release of granisetron over several days, offering convenience compared to oral medications that require frequent dosing.
- The patch provides long-lasting relief, covering the duration of chemotherapy treatment without the need for multiple doses.
- Sancuso offers a non-invasive treatment option for patients, making it easier for those who have difficulty taking oral medications or have nausea that makes swallowing pills challenging.
Direction of Use
- Sancuso should be applied to clean, dry, and intact skin on the upper outer arm or on the chest. It should be applied at least 24-48 hours before the start of chemotherapy treatment.
- The patch can be worn for up to 7 days and should be replaced according to the healthcare provider’s instructions.
- After the treatment period (usually after 24-48 hours of chemotherapy), the patch should be removed and disposed of as directed.
- It is important to apply the patch as recommended to ensure effective symptom control throughout chemotherapy. If the patch becomes dislodged, it should be replaced with a new one.
Safety Concerns
- Some patients may experience skin irritation or allergic reactions at the site where the patch is applied. It’s important to monitor the application site for any signs of redness, swelling, or rash.
- While granisetron is effective in preventing nausea and vomiting, some patients may experience constipation, which can occur as a side effect.
- Rarely, granisetron may cause QT interval prolongation, which can increase the risk of heart arrhythmias. Patients with existing heart conditions should be monitored closely.
- Though rare, serotonin syndrome (a potentially life-threatening condition) can occur if Sancuso is used with other medications that increase serotonin levels, such as certain antidepressants.
- The safety of Sancuso during pregnancy or breastfeeding has not been well established, so it should only be used when necessary and prescribed by a healthcare provider.
Avoid Sancuso (Granisetron) If
- If you are allergic to granisetron or any of the ingredients in the patch, you should avoid using Sancuso.
- Sancuso should not be used in patients with certain types of gastrointestinal blockages or conditions that may interfere with the absorption of the medication.
- Patients with a history of heart problems, particularly those with a prolonged QT interval, should not use Sancuso without careful monitoring, as it may increase the risk of arrhythmias.
- Avoid using Sancuso in combination with other medications that can increase serotonin levels in the body, such as selective serotonin reuptake inhibitors (SSRIs), as this may increase the risk of serotonin syndrome.
- Sancuso should only be used during pregnancy or breastfeeding if the potential benefits outweigh the risks, and it should only be prescribed by a healthcare provider after a careful evaluation.
