Information about Tabloid (Thioguanine)
Tabloid is a prescription medication containing thioguanine, a chemotherapy drug that belongs to the class of purine antimetabolites. Thioguanine works by interfering with the DNA and RNA production in rapidly growing cells, such as cancer cells, thereby slowing down or stopping their growth. Tabloid is mainly used in the treatment of certain types of cancer, including leukemia. It is often used as part of a combination chemotherapy regimen.
Product Highlights
- Tabloid is commonly used to treat certain types of leukemia, specifically acute non-lymphocytic leukemia (ANLL).
- It is sometimes used in combination with other drugs to treat different forms of leukemia or other blood cancers.
- Thioguanine may be used in the treatment of other types of cancer, although it is primarily indicated for leukemia.
Key Ingredient
Key Benefits
- Tabloid works by inhibiting DNA and RNA synthesis, which prevents the proliferation of cancer cells, thus helping to control the growth of leukemia.
- It is particularly effective in treating acute non-lymphocytic leukemia (ANLL) and is often used in combination with other chemotherapy agents.
- As an oral tablet, Tabloid provides a convenient method of taking the medication, which can be easier for patients compared to intravenous chemotherapy.
- When combined with other drugs, it can enhance the overall effectiveness of leukemia treatment and may reduce the chances of relapse.
Direction of Use
- Tabloid is taken orally in the form of a tablet, typically once or twice daily, as directed by a healthcare provider.
- The dosage is tailored to the patient's condition, treatment response, and other individual factors. A healthcare provider will establish the correct dosage and treatment duration.
- It can generally be taken with or without food, but it’s recommended to follow the instructions given by the healthcare provider to optimize absorption.
- Regular blood tests and other medical monitoring are essential during treatment to assess the drug’s effectiveness and to detect potential side effects, particularly those related to liver function.
Safety Concerns
- Thioguanine can cause suppression of bone marrow activity, leading to a decrease in red blood cells, white blood cells, and platelets, which may increase the risk of infections, anemia, and bleeding. Regular blood tests are required to monitor these levels.
- Thioguanine is metabolized by the liver, and liver function may be affected. Liver enzyme levels should be monitored regularly during treatment.
- Nausea, vomiting, and diarrhea are common side effects. Patients may also experience mucositis (inflammation of the mucous membranes), which can cause sores in the mouth and throat.
- Due to immune suppression, patients may be at increased risk for infections.
- Thioguanine can pose risks to a fetus and should be avoided during pregnancy. It may also affect fertility in both men and women, so contraception is recommended during treatment.
Avoid Tabloid (Thioguanine) If
- Thioguanine is contraindicated during pregnancy due to potential harm to the fetus.
- Avoid using Tabloid while breastfeeding, as it may be excreted in breast milk and could harm the infant.
- Patients with severe liver disease or impaired liver function should avoid thioguanine or use it with caution under strict medical supervision.
- If there is already a significant reduction in bone marrow function, thioguanine should not be used or should be used with extreme caution.
- If a patient is allergic to thioguanine or any of its components, the medication should be avoided.
