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According to the European Medicines Agency, brand name Lonsurf originating from Europe is manufactured at the following site(s):
Les Laboratoires Servier Industrie
905, route de Saran
45520 Gidy
France
Servier (Ireland) Industries Limited
Gorey Road,
Arklow,
Co. Wicklow,
Y14 E284,
Ireland
Information about Lonsurf (Trifluridine / Tipiracil)
Lonsurf is a combination medication containing trifluridine and tipiracil, used primarily in the treatment of metastatic colorectal cancer. Trifluridine is an antineoplastic agent, while tipiracil is included to enhance the efficacy of trifluridine by inhibiting its breakdown.
Product Highlights
- Indicated for patients who have received prior treatments and whose disease is not amenable to curative treatment.
Key Ingredient
Key Benefits
- Specifically formulated for patients with advanced colorectal cancer.
- Has been shown to extend overall survival in some patients compared to standard treatments.
- Oral formulation allows for ease of use compared to intravenous therapies.
Direction of Use
- Follow the prescribed dosage from your healthcare provider.
- Take the tablets with water, preferably with food to improve absorption.
- Typically taken twice daily for 5 days, followed by a 2-day rest period in a 28-day cycle.
Safety Concerns
- May include nausea, vomiting, diarrhea, fatigue, and low blood cell counts (neutropenia).
- Regular blood tests may be necessary to monitor blood cell levels and liver function.
- Due to potential low white blood cell counts, there is an increased risk of infections.
Avoid Lonsurf (Trifluridine / Tipiracil) If
- You have a known allergy to trifluridine, tipiracil, or any of the components of the medication.
- Not suitable for individuals with significant bone marrow suppression.
- Not recommended during pregnancy because of the potential risk to the fetus.
- Caution is advised in patients with significant liver impairment.
