Information about Targretin (Bexarotene)
Targretin is a prescription medication that contains the active ingredient bexarotene, a retinoid used primarily to treat certain types of cancer, particularly cutaneous T-cell lymphoma (CTCL). It works by altering the behavior of cancerous cells and stimulating them to mature, which can help control the spread of the disease.
Product Highlights
- Targretin is used for the treatment of CTCL in patients who have not responded to other treatments or for whom other treatments are not appropriate.
- Targretin may sometimes be used off-label for other conditions, such as certain forms of leukemia or other cancers, though these uses are less common.
Key Ingredient
Key Benefits
- Targretin has been shown to help manage symptoms of cutaneous T-cell lymphoma by reducing skin lesions and improving overall skin health.
- Available both as oral capsules for internal use and as a topical gel for direct application to affected skin areas, providing flexibility in treatment.
- Targretin is particularly effective in improving skin-related symptoms of CTCL, including rash, lesions, and inflammation.
Direction of Use
- For CTCL, the usual dose is 300 mg per day, taken in one or two divided doses with food. The exact dose and duration depend on the patient’s response and tolerance.
- Apply the gel to affected skin areas once or twice daily, depending on the physician’s recommendations. The gel should be applied to clean, dry skin and gently rubbed in.
- For best results, Targretin should be used consistently as directed by a healthcare provider, and doses should not be missed.
Safety Concerns
- Common side effects may include headaches, dry skin, itching, nausea, and fatigue. It can also cause elevated cholesterol and triglyceride levels, liver enzyme changes, and skin irritation.
- Rare but serious side effects include pancreatitis, liver toxicity, and changes in lipid levels that may require monitoring and treatment adjustments.
- Since Targretin can cause elevated cholesterol and triglycerides, regular blood tests are necessary to monitor lipid levels.
- Targretin can cause birth defects and should not be used during pregnancy or while breastfeeding. Women of childbearing age should use reliable contraception during treatment and for a period of time after stopping the medication.
- Liver function should be monitored regularly due to the potential for liver toxicity.
- Targretin may alter thyroid function, and patients should be monitored for thyroid abnormalities.
Avoid Targretin (Bexarotene) If
- Targretin is contraindicated in pregnant women due to its potential for causing birth defects. It should also be avoided during breastfeeding.
- If you have severe liver impairment or active liver disease, you should avoid using Targretin.
- Do not use Targretin if you are allergic to bexarotene or any other retinoids.
- Patients with uncontrolled high cholesterol or triglycerides should avoid Targretin, or it should be used with extreme caution.
- If you have thyroid problems, Targretin should be used with caution, and thyroid function should be monitored regularly.
