ALOXI Injection, containing Palonosetron, is primarily used to prevent nausea and vomiting induced by chemotherapy treatments.
ALOXI is used in children 1 month old to less than 17 years of age, with certain anti-cancer medicines (chemotherapy).
Product Highlights
Effective in preventing acute and delayed nausea and vomiting associated with chemotherapy.
Administered via injection, ensuring rapid onset of action and reliable absorption.
Key Ingredients
Palonosetron hydrochloride
Mannitol
Disodium edetate and citrate buffer in water
Key Benefits
Provides significant relief from chemotherapy-induced nausea and vomiting.
Longer duration of action compared to other antiemetics, reducing the need for additional medication.
Well-tolerated with minimal side effects.
Direction For Use
ALOXI Injection is typically administered intravenously, either as a single dose before chemotherapy or as directed by a healthcare provider.
The dosage may vary depending on individual patient factors and the specific chemotherapy regimen.
DOSAGE AND ADMINISTRATION
Age
Dose
Infusion Time
Adults
Adults
Infuse over 30 seconds beginning approx. 30 min before the start of chemo.
Pediatrics (1 month to less than 17 years)
20 micrograms per kilogram (max 1.5 mg) x 1
Infuse over 15 minutes beginning approx. 30 min before the start of chemo
Safety Concern
Seek immediate medical attention if signs of an allergic reaction (e.g., rash, itching, and swelling) occur.
Palonosetron may prolong QT interval in some patients; caution is advised in individuals with cardiac conditions or those taking medications affecting heart rhythm.
Other common side effects include headache, constipation, and fatigue.
Avoid Taking ALOXI Injection if you:
Are allergic to palonosetron or any ingredients in the formulation.
Have a history of severe reactions to other serotonin 5-HT3 receptor antagonists.
Are pregnant or breastfeeding without medical advice, as the safety of palonosetron in these conditions has not been fully established.
