Kuvan (Sapropterin)

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Brand Name : Kuvan

Marketing Authorization Holder : Biomarin

Prescription Required

 
 
No Generic Medicine available for this medicine.

Product Details

Kuvan

Information about Kuvan (Sapropterin)

Kuvan is a medication that contains sapropterin dihydrochloride, a synthetic form of the naturally occurring tetrahydrobiopterin (BH4). It is used to manage phenylketonuria (PKU), a genetic disorder that leads to the accumulation of phenylalanine in the body.

Product Highlights

  • Indicated for the treatment of PKU in patients who have some residual enzyme activity, allowing for dietary flexibility and improved metabolic control.

Key Ingredient

  • Sapropterin Dihydrochloride

Key Benefits

  • Helps lower blood phenylalanine levels in patients with PKU.
  • Allows patients to expand their dietary choices, which can improve quality of life.
  • Generally well-tolerated with a favorable safety profile.

Direction of Use

  • Dosing is individualized based on the patient's phenylalanine levels and clinical response; typically starts at 10 mg/kg/day.
  • The powder can be mixed with soft foods or liquids; tablets should be swallowed whole.

Safety Concerns

  • Common side effects may include nausea, diarrhea, and abdominal pain.
  • Rarely, patients may experience allergic reactions; monitoring for symptoms is advised.
  • Regular monitoring of blood phenylalanine levels is necessary to adjust dosage and ensure effectiveness.

Avoid Kuvan (Sapropterin) If

  • Patients with a known allergy to sapropterin or any of its components should avoid use.
  • Not recommended for patients with uncontrolled PKU or those who do not have residual enzyme activity.
  • Consult a healthcare provider regarding use during pregnancy and breastfeeding, as safety data is limited.


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