Save over 50% with brand name Ofev from Europe and 95% with generic versions of Ofev today. Ofev in Europe may go by trade names Cyendiv and Vargatef.
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According to the European Medicines Agency, brand name Ofev originating from Europe is manufactured at the following site(s):
Boehringer Ingelheim Pharma GmbH & Co. KG
Binger Strasse 173
55216 Ingelheim am Rhein
Germany
Boehringer Ingelheim France
100-104 Avenue de France
75013 Paris
France
Information about Ofev (Nintedanib)
Ofev is the brand name for nintedanib, an oral medication used primarily in the treatment of certain chronic lung diseases, such as idiopathic pulmonary fibrosis (IPF), as well as for the treatment of non-small cell lung cancer (NSCLC) and systemic sclerosis-associated interstitial lung disease (SSc-ILD). Nintedanib is a multi-kinase inhibitor that works by targeting various signaling pathways involved in fibrosis, inflammation, and cancer cell growth.
Product Highlights
- Ofev is used to treat idiopathic pulmonary fibrosis, a progressive and debilitating lung disease that causes scarring (fibrosis) of lung tissue, leading to difficulty breathing.
- Ofev is indicated to treat interstitial lung disease associated with systemic sclerosis (a type of autoimmune disease).
- Ofev is used in combination with other therapies to treat certain forms of non-small cell lung cancer that has spread (metastatic NSCLC) or is advanced.
Key Ingredient
Key Benefits
- Ofev helps to slow the decline in lung function and can delay the worsening of symptoms.
- By inhibiting the pathways responsible for fibrosis, Ofev helps reduce scarring in the lungs and other affected tissues.
- For patients with IPF or SSc-ILD, Ofev has been shown to improve long-term outcomes and survival.
- In combination with chemotherapy or other treatments, Ofev helps manage advanced or metastatic non-small cell lung cancer by inhibiting cancer cell growth.
- Ofev is taken as a tablet, which is convenient for long-term management of chronic conditions like IPF.
Direction of Use
- The recommended dose of Ofev is 150 mg twice daily. It should be taken with food to reduce the risk of gastrointestinal side effects.
- The tablets should be swallowed whole with water. If you miss a dose, take it as soon as you recall, unless it's almost time for your next dose. In that case, skip the missed dose and resume your normal dosing schedule. Do not take two doses at the same time.
- The dose may be adjusted based on the patient's tolerance, particularly if side effects like diarrhea or liver enzyme abnormalities occur.
- Treatment is generally long-term, and the duration depends on the patient's response and the condition being treated.
Safety Concerns
- Common side effects include diarrhea, nausea, vomiting, and abdominal pain. Patients should be monitored for signs of dehydration and electrolyte imbalances, especially with persistent diarrhea.
- Nintedanib can cause liver enzyme elevations. Regular liver function tests (LFTs) are recommended before starting treatment and during treatment.
- Ofev may increase blood pressure. Blood pressure should be monitored regularly.
- Ofev may increase the risk of bleeding, particularly in patients with underlying bleeding disorders or who are using anticoagulant medications.
- Some patients may experience heart problems, such as arrhythmias, so monitoring is required, especially for patients with pre-existing heart conditions.
- Ofev is not recommended during pregnancy as it may harm the fetus. It should also not be used while breastfeeding due to potential risks to the baby.
Avoid Ofev (Nintedanib) If
- You are pregnant or planning to become pregnant, as Ofev can cause harm to an unborn baby.
- You are breastfeeding, as the medication can pass into breast milk and may harm the infant.
- You have liver disease, particularly if you have a history of severe liver impairment (Ofev should be avoided in such cases or used with caution under strict monitoring).
- You have active bleeding disorders or a history of significant bleeding, as Ofev increases the risk of bleeding.
- You are allergic to nintedanib or any of the ingredients in Ofev.
- You have severe hypertension that is not well controlled, as Ofev may elevate blood pressure and worsen cardiovascular issues.
