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Information about Tracleer (Bosentan)
Tracleer is a prescription medication that contains bosentan, an endothelin receptor antagonist used primarily in the treatment of pulmonary arterial hypertension (PAH). It works by blocking the effects of endothelin, a substance in the blood vessels that can cause constriction and narrowing of the blood vessels. By inhibiting endothelin, Tracleer helps to relax and widen the blood vessels, improving blood flow and reducing the workload on the heart. Tracleer is also used to treat certain types of chronic liver disease in combination with other therapies.
Product Highlights
- Tracleer is primarily prescribed for the treatment of PAH, a condition where high blood pressure affects the arteries in the lungs, leading to difficulty breathing and strain on the heart.
- Tracleer may also be prescribed to reduce the risk of complications associated with pulmonary hypertension in patients with sickle cell disease.
Key Ingredient
Key Benefits
- Tracleer helps to lower blood pressure in the lungs, which reduces the strain on the heart and improves symptoms in individuals with PAH.
- By improving circulation and reducing PAH symptoms, Tracleer can help improve exercise tolerance and overall physical function in patients with pulmonary hypertension.
- Tracleer helps protect the heart from excessive strain caused by pulmonary hypertension, reducing the risk of heart failure and related complications.
- As symptoms such as shortness of breath, fatigue, and dizziness are reduced, patients often experience an improved quality of life and better functional capacity.
Direction of Use
- The usual starting dose for adults is 62.5 mg once daily for the first 4 weeks. After the initial period, the dose is typically increased to 125 mg once daily.
- Tracleer tablets should be taken orally with or without food. Swallow the tablets whole without crushing, chewing, or breaking them.
- Patients on Tracleer must undergo regular liver function tests to monitor for potential liver toxicity, as bosentan can affect liver enzymes.
- If you forget a dose, take it as soon as you remember, unless it's nearly time for your next dose. In that situation, skip the missed dose and resume your usual dosing routine. Do not take two doses to make up for a missed dose.
- Tracleer should be avoided during pregnancy, and effective contraception should be used while on this medication due to potential harm to the fetus.
Safety Concerns
- One of the most significant safety concerns with Tracleer is its potential to cause liver damage. Liver function tests must be performed regularly to monitor for signs of liver toxicity.
- Bosentan can cause serious birth defects and should not be taken during pregnancy. Women of childbearing potential must use effective contraception during treatment and for at least 1 month after stopping the medication.
- Tracleer may cause a decrease in red blood cells, leading to anemia, which can result in fatigue, dizziness, and weakness. Regular blood tests should be done to monitor for this condition.
- As Tracleer can dilate blood vessels, it may cause low blood pressure (hypotension), especially during the early stages of treatment.
- These are common side effects that some patients may experience while taking Tracleer.
- Swelling in the lower limbs (edema) is another possible side effect that patients should monitor for during treatment.
Avoid Tracleer (Bosentan) If
- You are pregnant or planning to become pregnant, as bosentan can cause harm to the developing fetus.
- You have severe liver impairment or elevated liver enzyme levels, as Tracleer can worsen liver damage.
- You are allergic to bosentan or any other ingredient in the medication.
- You are taking cyclosporine A or glyburide (a specific class of drugs), as these can interact with Tracleer and increase the risk of side effects.
- You are using other endothelin receptor antagonists or drugs that may interact negatively with bosentan.
