Depen (Penicillamine)

Information about Depen (Penicillamine)

Depen is a prescription medication used primarily as a chelating agent to treat conditions involving excess metal accumulation in the body. It works by binding to metals such as copper, lead, and mercury, facilitating their removal from the body. Penicillamine is also used in the management of certain autoimmune conditions and as a disease-modifying agent in rheumatoid arthritis.

Product Highlights

• Treatment of copper accumulation in the liver and brain.
• Chelation therapy for lead toxicity.
• As a disease-modifying agent to manage symptoms in patients with rheumatoid arthritis.
• Reducing the formation of kidney stones by binding to cystine in the urine.

Key Ingredient

• Penicillamine

Key Benefits

• Effectively removes excess copper, lead, and other metals from the body.
• Helps to slow disease progression and manage symptoms in rheumatoid arthritis.
• Aids in reducing the formation of cystine stones in cystinuria.

Direction of Use

• The dosage varies based on the condition being treated. For Wilson’s disease, it typically starts at 250 mg to 500 mg daily, which may be adjusted based on clinical response and copper levels. For rheumatoid arthritis, it usually starts at 125 mg to 250 mg daily, with possible adjustments.
• Take Depen orally on an empty stomach, at least 1 hour before or 2 hours after meals. Take the tablets whole with a full glass of water.

Safety Concerns

• May include nausea, vomiting, loss of appetite, and skin rash. Some patients may experience a metallic taste or changes in taste perception.
• Risk of severe allergic reactions, bone marrow suppression, kidney damage, and liver toxicity. Regular monitoring of blood counts and kidney function is recommended.
• Routine blood tests and monitoring of kidney function and copper levels are advised during treatment.

Avoid Depen (Penicillamine) If

• You have a known hypersensitivity to Penicillamine or any of its components.
• Avoid use if you have severe kidney or liver impairment due to the risk of exacerbating these conditions.
• The safety of Depen during pregnancy has not been well established. It should be used only when the potential benefits outweigh the risks and under the direction of a healthcare provider.
• Avoid use if you have certain autoimmune conditions that may worsen with Penicillamine.