Primaquine

Information about Primaquine

Primaquine is an antimalarial medication primarily used to treat and prevent malaria. It is effective against the liver stages of Plasmodium species, which cause malaria. It is often used in combination with other antimalarial drugs to ensure a comprehensive treatment approach.

Product Highlights

• Used to treat malaria caused by Plasmodium vivax and Plasmodium ovale, specifically to eliminate the dormant liver forms (hypnozoites) and prevent relapse.
• Sometimes used in combination with other drugs for the prevention of malaria.
• Primaquine is used in combination with other medications to ensure a radical cure for malaria, preventing recurrence caused by liver-stage parasites.

Key Ingredient

• Primaquine

Key Benefits

• Effective in eradicating the liver stage of the malaria parasite, reducing the risk of relapse in patients with Plasmodium vivax and Plasmodium ovale infections.
• A critical part of malaria treatment, especially when combined with other drugs.
• Helps achieve a radical cure by clearing both the blood and liver stages of the malaria parasite, preventing future outbreaks.

Directions for Use

• The typical dosage for adults is 26.3 mg daily for 14 days for the treatment of Plasmodium vivax malaria. Dosage may vary based on the severity of the infection and the presence of other health conditions.
• The tablet should be taken orally with food to reduce the risk of gastrointestinal upset.
• Always finish the full prescribed treatment to ensure complete elimination of the parasite. Do not stop taking the medication prematurely.

Safety Concerns

• Primaquine should not be used in patients with G6PD deficiency, as it can lead to severe hemolysis (destruction of red blood cells).
• Possible side effects include nausea, vomiting, stomach cramps, headache, and dizziness. Serious side effects, although rare, may include hemolytic anemia (especially in those with G6PD deficiency) and arrhythmias.
• Primaquine is generally not recommended during pregnancy, particularly during the first trimester, unless the potential benefits outweigh the risks. It passes into breast milk, so breastfeeding mothers should use caution. 

Avoid Primaquine If

• Avoid use in patients with G6PD deficiency due to the risk of hemolysis.
• Should be avoided during pregnancy, particularly in the first trimester, unless prescribed by a doctor after careful consideration of risks and benefits.
• If you have a known hypersensitivity or allergy to primaquine or any other component of the drug.
• Avoid in patients with significant liver dysfunction or disease unless otherwise directed by a healthcare provider.