Creon (Pancreatin)

Brand Options

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Brand Name : Creon

Marketing Authorization Holder : AbbVie

Prescription Required

 
 

Generic Option

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Generic Name : enzymes

Manufactured By : Authorized Indian Generic

Prescription Required

 
 

Product Details

Creon

Creon 10 (also called Creon 10,000)

Lipase10,000 PhEur units (=10,000 USP units)
Amylase8,000 PhEur units (= 33,200 USP units)
Protease600 PhEur units (= 37,500 USP units)

Creon 25:

Lipase25,000 PhEur units ( = 25,000 USP units)
Amylase18,000 PhEur units (= 74,700 USP units)
Protease1,000 PhEur units (= 62,500 USP units)

Creon 40: Lipase 40,000 - Amylase 103,750 USP (25,000 EU) - Protease 100,000 USP (1600 EU)

Here are the US version of Creon:

CREON is available in US most commonly in capsule strengths of:

 ● 6,000 USP units of lipase; 19,000 USP units of protease; 30,000 USP units of amylase

 ● 12,000 USP units of lipase; 38,000 USP units of protease; 60,000 USP units of amylase

 ● 24,000 USP units of lipase; 76,000 USP units of protease; 120,000 USP units of amylase

They also have:  36,000 USP units of lipase, 114000 units of protease, 180,000 USP units of amylase

Information about Creon (Pancreatin)

Creon is a prescription medication that contains pancreatin, a mixture of digestive enzymes including amylase, lipase, and protease. It is used to aid digestion in individuals whose pancreas does not produce enough enzymes naturally. By supplementing these essential enzymes, Creon helps improve digestion and nutrient absorption.

Product Highlights

  • Provides a combination of digestive enzymes to assist in the breakdown and absorption of fats, proteins, and carbohydrates.
  • Available in different strengths and formulations to accommodate varying patient needs and levels of pancreatic insufficiency.
  • Used in patients with conditions such as cystic fibrosis, chronic pancreatitis, or pancreatic cancer that lead to inadequate pancreatic enzyme production.
  • Helps in managing symptoms related to malabsorption and poor digestion due to enzyme deficiencies.

Key Ingredient

  • Pancreatin

Key Benefits

  • Enhances the digestion of nutrients, helping to alleviate symptoms such as bloating, gas, and diarrhea.
  • Assists in the effective absorption of vital nutrients, which can improve overall health and energy levels.
  • Provides relief from digestive issues associated with pancreatic insufficiency.

Direction of Use

  • Typically taken with meals and snacks, as directed by a healthcare provider. The dosage depends on the specific formulation and the degree of pancreatic insufficiency.
  • Swallow the capsules whole with a generous amount of water. If difficulty swallowing, capsules can be opened and the contents mixed with applesauce or another soft food, but do not chew the beads.

Weight Based Dosing Recommendations for the Treatment of Paediatric and Adult Patients with Cystic Fibrosis (CF) using Creon

Patient AgeStarting DoseTitration ConsiderationsMaximum Dose
Children < 4 years1,000 units lipase/kg bodyweight per meal

Adjust dose according to:

• disease severity

• control of steatorrhoea

• maintenance of good nutritional status

4,000 units lipase/g dietary fat intake

OR

10,000 units lipase/kg bodyweight per day

Patients ≥ 4 years500 units lipase/kg bodyweight per meal

Dosing Recommendations in Adult Patients using Creon for the Treatment of Pancreatic Exocrine Insufficiency (PEI) Associated with other Conditions


 
Starting DoseTitration ConsiderationsIf required, increase to:
Meal25,000 to 40,000 units lipaseAssess patient for clinical response and compliance to therapy.80,000 units lipase
SnackHalf of meal doseHalf of meal dose

Safety Concerns

  • May include gastrointestinal symptoms such as nausea, diarrhea, constipation, or stomach pain.
  • Rarely, can cause allergic reactions or unusual symptoms related to enzyme overdose, such as abdominal pain or severe digestive upset.
  • Regular follow-up with a healthcare provider is important to adjust dosage and monitor for any adverse effects.

Avoid Creon (Pancreatin) If

  • You have a known hypersensitivity or allergy to pancreatin or any component of Creon.
  • Avoid use in cases of acute pancreatitis or conditions that require temporary cessation of enzyme therapy.
  • Caution is needed if you have a history of ulcers, or if you are taking medications that interact with digestive enzymes. Consult a healthcare provider to confirm that it is suitable for your condition.


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