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Information about Qtern (Saxagliptin/Dapagliflozin)
Qtern is a combination medication containing two active ingredients: Saxagliptin and Dapagliflozin. It is used to help control blood sugar levels in adults with type 2 diabetes, when diet and exercise alone are insufficient. Saxagliptin is a DPP-4 inhibitor, which helps to increase insulin production and decrease glucose production in the liver. Dapagliflozin is an SGLT2 inhibitor, which works by reducing the amount of glucose reabsorbed by the kidneys, thus helping to lower blood sugar levels. The combination of these two drugs provides complementary actions to manage blood sugar more effectively.
Product Highlights
- It is used together with diet and exercise to help manage blood sugar levels in adults with type 2 diabetes. It is often prescribed when other medications have not been effective or when more than one approach is required for optimal blood glucose management.
Key Ingredient
Key Benefits
- The combination of saxagliptin and dapagliflozin offers two complementary mechanisms to help regulate blood sugar levels.
- Helps to reduce HbA1c levels (a marker of long-term blood sugar control), improving overall management of type 2 diabetes.
- Qtern is taken once daily, making it easier for patients to adhere to their medication regimen.
- Dapagliflozin may also help with mild weight loss as it promotes the excretion of glucose through urine.
- Dapagliflozin has shown some benefits in reducing the risk of hospitalization for heart failure and can be beneficial in patients with heart-related issues.
Direction of Use
- Qtern is usually taken once a day, with or without food.
- The recommended dose is usually one tablet daily, but the exact dose will depend on the patient's specific medical condition and treatment plan.
- The tablet should be swallowed whole and not split, crushed, or chewed.
- It is important for patients to follow the prescribed dosage and not to adjust the dose without consulting a healthcare provider.
Safety Concerns
- Dapagliflozin can affect kidney function, and it is essential to monitor kidney health regularly during treatment.
- SGLT2 inhibitors like dapagliflozin may cause low blood pressure, especially in patients who are dehydrated or are on diuretics.
- Dapagliflozin increases the risk of urinary tract infections and genital infections due to the increased glucose in the urine.
- Although rare, patients taking SGLT2 inhibitors may be at an increased risk of DKA, a serious condition where the body produces high levels of ketones.
- Saxagliptin, similar to other DPP-4 inhibitors, may elevate the risk of pancreatitis (inflammation of the pancreas).
- While Qtern itself is unlikely to cause low blood sugar, combining it with other diabetes medications (such as insulin or sulfonylureas) may increase the risk of hypoglycemia.
Avoid Qtern (Saxagliptin/Dapagliflozin) If
- Qtern should be avoided in patients with severe kidney impairment or those on dialysis, as dapagliflozin may worsen kidney function.
- If you have had an allergic reaction to saxagliptin, dapagliflozin, or any other ingredient in Qtern, you should avoid taking it.
- Qtern is not advised for use in patients with type 1 diabetes or diabetic ketoacidosis (DKA).
- The safety of Qtern during pregnancy has not been established, so it should be avoided unless clearly needed and prescribed by a healthcare provider.
- It is not known whether Qtern passes into breast milk, so caution is recommended if breastfeeding or planning to breastfeed.
- Qtern should be used with caution in patients who are dehydrated, have low blood pressure, or have conditions that predispose them to low blood pressure.
