Save 60% on brand Astagraf XL - Astragraf XL is called Advagraf internationally.
Manufacturer for Advagraf (ER Tacrolimus) in Europe: Astellas Ireland Co., Ltd. Killorglin, County Kerry, V93FC86 Ireland
Astagraf XL (Tacrolimus ER)
Astagraf XL (Tacrolimus ER) is an extended-release formulation of tacrolimus, a medication primarily used in immunosuppressive therapy. Astagraf XL is used to prevent organ rejection in transplant patients.
It is often prescribed for individuals who have undergone kidney, liver, or heart transplants. Tacrolimus works by suppressing the immune system to prevent it from attacking the transplanted organ.
Product Highlights
Extended-Release formulation designed to release tacrolimus gradually, allowing for once-daily dosing.
Improved adherence the extended-release form can help in maintaining steady blood levels of the medication, which might improve patient compliance.
Tacrolimus active ingredient in Astagraf XL. It is a potent immunosuppressant that inhibits T-cell activation and proliferation, crucial for preventing transplant rejection.
Key Ingredients
Tacrolimus
Key Benefits
Effective immunosuppression reduces the risk of transplant rejection by inhibiting the immune response.
Convenience the extended-release formulation allows for once-daily dosing, which can be more convenient than other forms that require multiple doses per day.
Stable blood levels helps maintain more consistent tacrolimus levels in the bloodstream, potentially leading to better efficacy and fewer side effects.
Direction For Use
Typically taken once daily, with or without food. The exact dosage is individualized based on patient needs and blood levels of tacrolimus.
Swallow the tablets whole; do not chew or crush them. Consistent timing with respect to meals is usually recommended for optimal absorption.
7 to 15 ng/mL (with basiliximab induction) 10 to 15 ng/mL (without basiliximab induction)
Months 2 to 6
5 to 15 ng/mL
> 6 Months
5 to 10 ng/mL
Safety Concern
Regular blood tests are needed to monitor tacrolimus levels and adjust the dose to avoid toxicity or under-dosing.
Includes risk of kidney damage, high blood pressure, diabetes, and increased susceptibility to infections. Patients should be monitored for these and other potential side effects.
Avoid Astagraf XL (Tacrolimus ER) If
You have a known allergy to tacrolimus or any other component of the formulation.
Patients with severe liver dysfunction may need an alternative medication or dose adjustment.
Caution is needed if you are taking other medications that significantly interact with tacrolimus, as this could affect drug levels and increase the risk of side effects.
The product may appear different from the product illustrated here
