Save over 20% on Avyakit, called Ayvakt in Europe.
Non-english packaging is often present for European medicines- English label and English insert included. Plan in advance - allow us 7 days to ship this brand name medicine.
According to the European Medicines Agency, brand name Avyakit originating from Europe is manufactured at the following site(s): Blueprint Medicines (Netherlands) B.V. Gustav Mahlerplein 2 1082 MA Amsterdam Netherlands
Information about Ayvakit (Avapritinib)
- Ayvakit (Avapritinib) is used primarily to treat certain types of cancers. It is specifically indicated for the treatment of adults with unresectable or metastatic gastrointestinal stromal tumors (GISTs) with a specific genetic mutation in the PDGFRα gene, including those with the D842V mutation.
- It is also used for other conditions associated with the mutation of the KIT or PDGFRα genes, such as certain cases of systemic mastocytosis.
Product Highlights
- Primarily used to treat adults with unrespectable or metastatic gastrointestinal stromal tumors (GISTs) harboring the PDGFRα D842V mutation.
- Also indicated for treatment of adults with systemic mastocytosis, including those with advanced forms of the disease.
- Avapritinib is a selective tyrosine kinase inhibitor. It specifically targets and inhibits the activity of PDGFRα (platelet-derived growth factor receptor alpha) and KIT (a type of receptor involved in cell signaling). This inhibition blocks the growth and proliferation of cancer cells that have these abnormal receptors.
Key Ingredients
- Avapritinib
- Copovidone
- Croscarmellose sodium
Key Benefits
- Specifically targets and inhibits the activity of abnormal tyrosine kinases associated with the growth of cancer cells in GISTs and systemic mastocytosis.
- Shows significant efficacy in treating GISTs with PDGFRα D842V mutations, which are resistant to many other treatments.
- May improve overall survival and quality of life for patients with these conditions.
Direction For Use
- The usual dosage of Ayvakit depends on the condition being treated and is determined by a healthcare provider. For GISTs, the typical dose is 300 mg taken orally once daily. For systemic mastocytosis, the dose may vary based on the specific type and severity.
- It is taken orally in the form of tablets. It should be swallowed whole, with or without food. The exact dosage and duration of treatment will be prescribed by a healthcare professional based on individual patient needs.
Safety Concern
- Common side effects are including nausea, vomiting, diarrhea, fatigue, edema, and abdominal pain.
- Regular monitoring by a healthcare provider is required to check for potential adverse effects and to adjust dosing as necessary.
Avoid Ayvakit (Avapritinib) If
- You have a known allergy or hypersensitivity to avapritinib or any of the inactive ingredients in the medication.
- You have severe liver dysfunction or other significant liver-related issues.
- Ayvakit should be avoided during pregnancy and breastfeeding unless the potential benefits outweigh the risks, as it may harm the developing fetus or a breastfeeding baby.
- Caution should be exercised if taking other medications that can interact with avapritinib, including certain drugs that affect liver enzymes.
