Information about Contrave (Naltrexone/Bupropion ER)
Contrave is a prescription medication that combines two drugs: naltrexone and bupropion, in extended-release (ER) form. It is used primarily for weight management in adults who are overweight or obese and have weight-related health conditions. The medication is designed to work as part of a comprehensive weight loss program that includes diet, exercise, and behavior modification.
Product Highlights
Intended for use in adults with a BMI of 30 kg/m² or greater (obese) or 27 kg/m² or greater (overweight) with at least one weight-related condition such as hypertension, type 2 diabetes, or dyslipidemia.
It should be used together with a reduced-calorie diet and increased physical activity.
Key Ingredients
Naltrexone
Bupropion
Key Benefits
It can result in substantial weight loss when used in conjunction with lifestyle changes.
Targets both appetite control and cravings through its dual ingredient formulation.
It may help manage emotional eating by targeting mood and cravings.
Direction of Use
Typically starts with a lower dose to minimize side effects, gradually increasing to the full therapeutic dose.
Take the tablets whole, without crushing or chewing, in the morning and evening.
It should be taken consistently every day as directed.
Dosage may be adjusted based on tolerability and clinical response, under the guidance of a healthcare provider.
Morning Dose
Evening Dose
Week 1
1 Tablet
None
Week 2
1 Tablet
1 Tablet
Week 3
2 Tablets
1 Tablet
Week 4 and afterward
2 Tablets
2 Tablets
Safety Concerns
Bupropion can increase the risk of seizures, especially in individuals with certain medical conditions or who are taking other medications that lower the seizure threshold.
May increase the risk of mood changes or psychiatric symptoms such as depression, anxiety, or suicidal thoughts.
Naltrexone can interfere with opioid use and may precipitate withdrawal symptoms in people using opioids.
Avoid Contrave (Naltrexone/Bupropion ER) If
You have a known allergy to naltrexone, bupropion, or any other ingredients in Contrave.
History of seizures or conditions that increase seizure risk.
Active bulimia or anorexia nervosa.
Current or recent use of opioid medications or dependence.
Contraindicated in severe liver impairment.
Safety in pregnancy and breastfeeding has not been established; avoid use unless prescribed by a healthcare provider.
The product may appear different from the product illustrated here
