Onglyza (Saxagliptin)

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Prescription Onglyza  is a  medicines used by adults to combat type 2 diabetes.  Onglyza along with exercise and good dietary habits can help lower your blood sugar and improve you A1C levels.  Onglyza has proven A1C success in diabetes treatment.  Onglyza is not for type 1 diabetes.

Onglyza works in your body by enhancing its own abilities to lower and control blood sugar levels.  With Onglyza, your body will increase insulin levels after meals and reduce the release of sugar between meals and overnight.  With Onglyza, you may find that your morning blood sugar is lower as Onglyza works overnight when you are asleep.  With Onglyza, you may find lower spikes in blood sugar after you eat.

Onglyza is taken only once per day, at the same time of day each time.  Onglyza is not for everyone.  Talk to your doctor if you are considering Onglyza.

People with diabetes must track their own blood sugar and the diet.  By doing this, your doctor can optimize your treatment schedule and give you the best possible outcome.  Keep a diary of your sugar levels and test your sugar as you doctor will request.

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Information about Onglyza (Saxagliptin)

Onglyza is a prescription medication that contains saxagliptin, an active ingredient belonging to the class of drugs known as DPP-4 inhibitors (dipeptidyl peptidase-4 inhibitors). It is primarily used in the management of type 2 diabetes. Saxagliptin works by increasing the levels of incretin hormones in the body, which help regulate blood sugar levels by stimulating insulin release and reducing the production of glucose by the liver. Onglyza is typically used as part of a comprehensive diabetes management plan that includes diet and exercise.

Product Highlights

• Onglyza is indicated for the management of type 2 diabetes mellitus. It helps to lower blood glucose levels in combination with diet and exercise.
• Onglyza is typically used when blood sugar is not adequately controlled with diet and exercise alone and can be added to other oral diabetes medications like metformin, sulfonylureas, or insulin.
• As a DPP-4 inhibitor, Onglyza has a low risk of causing hypoglycemia (low blood sugar) when used alone, although the risk may increase if combined with insulin or insulin secretagogues (e.g., sulfonylureas).

Key Ingredient

• Saxagliptin

Key Benefits

• Saxagliptin helps reduce blood sugar levels by enhancing insulin release and reducing the liver's glucose production, particularly after meals.
• When used alone, Onglyza carries a lower risk of causing hypoglycemia compared to other diabetes medications like sulfonylureas or insulin.
• Onglyza is taken once daily, which makes it a simple addition to a patient’s daily regimen.
• Unlike some other diabetes medications, Onglyza does not typically cause weight gain, which can be an important factor for many patients with type 2 diabetes.
• Onglyza can be used in combination with other diabetes medications, such as metformin, sulfonylureas, or insulin, for more comprehensive blood glucose management.

Direction of Use

• The typical recommended dose of Onglyza is 5 mg once daily, regardless of food intake.
• If used in combination with other medications (e.g., metformin or insulin), the dose of Onglyza may be adjusted as part of a comprehensive treatment plan.
• For patients with moderate renal impairment (eGFR 30-50 mL/min/1.73 m²), the dose may be reduced to 2.5 mg once daily. Onglyza is contraindicated in patients with severe renal impairment (eGFR <30 mL/min/1.73 m²).
• For best results, take Onglyza at the same time each day.

Safety Concerns

• There have been reports of pancreatitis (inflammation of the pancreas) in patients taking DPP-4 inhibitors like saxagliptin. If you experience severe abdominal pain, nausea, or vomiting, seek medical attention immediately.
• Saxagliptin has been associated with an increased risk of heart failure in certain patients, especially those with pre-existing heart or kidney problems. Monitoring for symptoms such as shortness of breath, edema (swelling), and rapid weight gain is recommended.
• Saxagliptin is cleared by the kidneys, so it may need to be dose-adjusted in patients with kidney problems. Regular kidney function monitoring is advised, especially in patients with renal impairment.
• While Onglyza itself does not typically cause low blood sugar, the risk of hypoglycemia may increase if used in combination with other medications that can lower blood glucose, such as insulin or sulfonylureas.
• Rarely, patients may experience allergic reactions to saxagliptin, including rash, itching, and swelling. If any allergic reactions occur, contact your doctor immediately.
• DPP-4 inhibitors like Onglyza can increase the risk of upper respiratory tract infections, urinary tract infections, and nasopharyngitis (common cold). If you develop signs of an infection, please consult your healthcare provider.

Avoid Onglyza (Saxagliptin) If

• You are allergic to saxagliptin or any other ingredients in Onglyza.
• You have severe kidney impairment (eGFR <30 mL/min/1.73 m²), as the medication is not recommended for those with severely impaired kidney function.
• You have a history of pancreatitis (inflammation of the pancreas).
• You are pregnant or planning to become pregnant, as the safety of Onglyza during pregnancy has not been established.
• You are breastfeeding, as it is not known whether saxagliptin passes into breast milk. Consult your doctor before using Onglyza if you are breastfeeding.
• You have a history of heart failure or are at high risk for heart failure, as saxagliptin may increase the risk of heart failure in some patients.