In the United Kingdom, Synjardy (empagliflozin / metformin) comes in 2 strengths, 5mg/1000mg and 12.5mg/1000mg not the lower doses of 5/500mg or 12.5/500mg which are available in the United States.
Prescription Synjardy is a combination drug used to help lower blood sugar and A1C levels in adults with type 2 diabetes who have known heart disease. The component of Synjardy called empagliflozin is shown to reduce the risk of cardiovascular death. Synjardy is used along with exercise and diet to improve their condition significantly. Synjardy can also cause mild weight loss, although it is not a weight loss drug. Synjardy can also lower your systolic blood pressure in some patients.
Synjardy works to improve blood sugar levels by removing excess sugar through the urine, creating less sugar in the liver, and reducing absorption of sugar after eating.
Synjardy is taken two times per day with food to reduce stomach side effects. Your physician will determine the best dose of Synjardy for you. Take Synjardy exactly as prescribed by your physician.
If Synjardy is used with other blood sugar medicines, you may need to lower the dose of your other medicines to reduce the risk of your blood sugar from going too low. Synjardy can be taken with insulin and other antidiabetic medicines.
Monitor your blood sugar regularly while taking Synjardy and keep track of the results to share with your healthcare team.
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Information about Synjardy (Empagliflozin / Metformin)
Synjardy is a combination medication containing two active ingredients: empagliflozin and metformin. Empagliflozin is an SGLT2 inhibitor, and metformin is classified as a biguanide. This combination is primarily used to help manage type 2 diabetes by improving blood sugar control. Empagliflozin works by helping the kidneys remove excess glucose from the blood, while metformin works by improving the body's sensitivity to insulin and reducing glucose production in the liver.
Product Highlights
- Synjardy is primarily prescribed for the following:
- To assist in reducing blood sugar levels in adults with type 2 diabetes. It is generally used when diet and exercise alone do not provide adequate control.
- In individuals with type 2 diabetes and existing cardiovascular disease, empagliflozin has been proven to lower the risk of heart failure and cardiovascular-related death.
- Taken alongside other diabetes medications or insulin, as prescribed by a healthcare provider.
Key Ingredient
Key Benefits
- Helps regulate blood glucose levels in type 2 diabetes.
- Empagliflozin may contribute to modest weight loss by excreting excess glucose through the urine.
- Empagliflozin has been shown to reduce the risk of cardiovascular events, particularly in patients with existing heart disease.
- Unlike some other diabetes medications, Synjardy does not typically cause hypoglycemia (low blood sugar) when used alone.
Direction of Use
- Take Synjardy exactly as prescribed by your healthcare provider.
- It is usually taken once or twice daily with meals to reduce gastrointestinal side effects.
- Swallow the tablet whole with a glass of water. Do not chew or crush the tablet.
- Monitor blood glucose regularly, and follow a proper diet and exercise regimen to help manage your diabetes effectively.
- The dosage may be adjusted based on your blood sugar levels and any other medical conditions you may have.
Safety Concerns
- Metformin can cause nausea, diarrhea, and stomach upset, especially when starting treatment.
- Empagliflozin can increase urination, which may lead to dehydration, especially in hot weather or during illness.
- Although uncommon, metformin can lead to a serious condition known as lactic acidosis, which requires urgent medical attention.
- Both empagliflozin and metformin can affect kidney function. Kidney function should be monitored regularly.
- Prolonged use of empagliflozin may cause low potassium or sodium levels.
Avoid Synjardy (Empagliflozin / Metformin) If
- You are allergic to empagliflozin, metformin, or any of the components in Synjardy.
- You have severe kidney or liver problems, as this can increase the risk of serious side effects.
- You are pregnant or breastfeeding, unless otherwise advised by a doctor.
- You have a history of metabolic acidosis, including diabetic ketoacidosis.
- You are experiencing dehydration, excessive alcohol consumption, or are severely ill.
- You have severe heart disease or a history of heart failure, as this can increase the risk of complications.
- You are planning or undergoing a contrast imaging procedure that may affect kidney function (such as a CT scan with contrast).
