Xifaxan (rifaximin) is called Targaxan in Europe. Although the medicine is exactly the same, the license holder Norgine Pharm has branded the product as Targaxan in the United Kingdom.
Prescription Xifaxan is an antibiotic used to treat inflammatory bowel disease with diarrhea. Xifaxan is the only approved treatment that works to inhibit the growth of bacteria in the gut that may be causing the condition.
After 2 weeks of Xifaxan treatment 52% of patients had abdominal pain relief, 76% had relief from diarrhea, and 47% saw relief from both abdominal pain and diarrhea.
Unlike other treatments, Xifaxan is only used as a short course therapy. It is usually given as a 2 week treatment and works for up to 6 months to provide symptom relief. Some patients will be required to undergo treatment more than once, however patients report recurring symptoms are less than before they had started with Xifaxan.
Although your dose and length of treatment may vary, the most common Xifaxan dose is 550mg Xifaxan 3 times per day taken with or without food.
If you continue to have diarrhea after taking Xifaxan, contact your doctor.
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Information about Xifaxan (Rifaximin)
Xifaxan is an oral antibiotic that works by targeting and inhibiting the growth of specific bacteria in the intestines. It is used primarily to treat gastrointestinal infections and conditions caused by bacterial imbalances. Unlike many other antibiotics, Xifaxan is not absorbed into the bloodstream in significant amounts, which allows it to work primarily in the intestines and reduces systemic side effects. It is commonly prescribed for traveler's diarrhea, irritable bowel syndrome with diarrhea (IBS-D), and hepatic encephalopathy.
Product Highlights
Xifaxan is used to treat traveler's diarrhea in adults and children over 12 years of age, caused by Escherichia coli (E. coli) bacteria.
It is prescribed to reduce the symptoms of IBS-D, including diarrhea and abdominal discomfort, in adults.
Xifaxan is used to reduce the recurrence of hepatic encephalopathy in patients with liver cirrhosis, a condition that affects brain function due to the buildup of toxins in the blood.
Key Ingredient
Rifaximin
Key Benefits
Xifaxan works primarily in the gastrointestinal tract, reducing the impact of bacteria on the digestive system while minimizing systemic side effects.
It is highly effective for treating traveler's diarrhea caused by E. coli and other gastrointestinal infections.
For people with IBS-D, Xifaxan can help reduce both diarrhea and abdominal pain, providing symptom relief.
In patients with liver cirrhosis, Xifaxan helps reduce the frequency of hepatic encephalopathy episodes, improving mental function and quality of life.
Direction of Use
The typical dose of Xifaxan is 200 mg to 550 mg, taken two to three times a day, depending on the condition being treated.
For traveler's diarrhea: Usually 200 mg three times a day for 3 days.
For IBS-D: Typically 550 mg three times a day for 14 days.
For hepatic encephalopathy: Usually 550 mg twice a day, continuing for long-term use.
Swallow the tablet whole with or without food. Do not chew or crush the tablet.
For best results, take the medication at evenly spaced intervals and complete the prescribed course, even if symptoms improve.
Condition
Recommended Dosage Regimen
TD
One 200 mg tablet 3 times a day for 3 days
HE
One 550 mg tablet 2 times a day
IBS-D
One 550 mg tablet 3 times a day for 14 days. Patients who experience recurrence can be retreated up to two times with the same regimen.
Safety Concerns
Common side effects may include nausea, abdominal pain, flatulence, or headache. These are usually mild and temporary.
Overuse of antibiotics like Xifaxan can lead to antibiotic resistance. Use only as prescribed and avoid unnecessary use.
Patients with liver disease should be monitored closely, as liver function can affect how the body processes Xifaxan.
Xifaxan is ineffective against viral infections (e.g., colds, flu) and should only be used for bacterial infections.
Prolonged use of antibiotics can sometimes lead to overgrowth of non-susceptible organisms, such as fungi or resistant bacteria, leading to new infections.
Avoid Xifaxan (Rifaximin) If
If you have a known allergy to rifaximin or any of the ingredients in Xifaxan, you should not take this medication.
Xifaxan is metabolized by the liver, so patients with severe liver impairment or cirrhosis should use caution, and dosing adjustments may be necessary.
Xifaxan should not be used for conditions like Clostridium difficile associated diarrhea, as it does not treat the underlying cause.
There is limited data on the safety of Xifaxan during pregnancy or breastfeeding. It should only be used if clearly necessary and under a doctor’s guidance.
