Seroquel XR (Quetiapine Extended Release) is an atypical antipsychotic medication that is primarily used to treat various mental health conditions such as schizophrenia, bipolar disorder, and major depressive disorder. The extended-release formulation helps provide more consistent symptom control over the course of the day.
Product Highlights
Used to manage symptoms of schizophrenia, including hallucinations, delusions, and disorganized thoughts.
Prescribed for the treatment of acute manic and depressive episodes, as well as for long-term maintenance.
Seroquel XR is used as an add-on treatment for major depressive disorder when other antidepressants alone do not provide sufficient relief.
Sometimes prescribed off-label for anxiety disorders.
Key Ingredient
Quetiapine
Key Benefits
The extended-release formulation of quetiapine allows for more consistent and prolonged symptom control, with fewer fluctuations in blood levels of the medication.
Seroquel XR is effective for managing a range of psychiatric disorders, including schizophrenia, bipolar disorder, and depression.
The extended-release formulation allows for once-daily dosing, which can improve patient compliance and convenience.
In some cases, Seroquel XR can help improve sleep in patients with mood disorders, particularly in those who experience insomnia as part of their condition.
Direction of Use
Seroquel XR is taken orally, typically once daily. It should be taken at the same time each day, preferably in the evening, as it can cause drowsiness.
The initial dose may vary depending on the condition being treated. For schizophrenia, the usual starting dose is 300 mg once daily, whereas for bipolar disorder, the dose may start at 50 mg and be increased gradually. For major depressive disorder, it’s typically used as an adjunctive treatment.
It is important to take the medication exactly as prescribed, without crushing or splitting the tablets. Do not adjust the dosage without medical advice.
Indication
Initial Dose
Recommended Dose
Maximum Dose
Schizophrenia - Adults
300 mg/day
400-800 mg/day
800 mg/day
Schizophrenia - Adolescents (13 to 17 years)
50 mg/day
400-800 mg/day
800 mg/day
Bipolar I Disorder manic or mixed - Acute monotherapy or adjunct to lithium or divalproex - Adults
300 mg/day
400-800 mg/day
800 mg/day
Bipolar I Disorder, manic Acute monotherapy - Children and Adolescents (10 to 17 years)
50 mg/day
400-600 mg/day
600 mg/day
Bipolar Disorder, Depressive Episodes - Adults
50 mg/day
300 mg/day
300 mg/day
Major Depressive Disorder, Adjunctive Therapy with Antidepressants - Adults
50 mg/day
150-300 mg/day
300 mg/day
Safety Concerns
Seroquel XR may cause drowsiness, especially when starting treatment or increasing the dose. Patients should avoid activities that require full alertness (e.g., driving) until they know how the medication affects them.
Quetiapine can cause weight gain, increased blood sugar, and higher cholesterol levels. Regular monitoring of weight, blood sugar, and lipid levels is recommended.
The drug may cause changes in heart rhythm (QT prolongation), which could be dangerous for individuals with pre-existing heart conditions.
Long-term use of quetiapine can increase the risk of movement-related side effects, such as tardive dyskinesia (involuntary muscle movements).
Like other antidepressants, Seroquel XR may increase the risk of suicidal thoughts or behavior, particularly in younger patients. Close monitoring is essential, especially during the early phases of treatment.
Seroquel XR should not be used in elderly patients with dementia-related psychosis due to an increased risk of death.
Avoid Seroquel XR (Quetiapine ER) If
Do not use Seroquel XR if you have a known allergy to quetiapine or any of its components.
Avoid using this medication if you have severe liver impairment, as it may worsen liver function.
Seroquel XR is not recommended for individuals with a history of heart problems, including arrhythmias or prolonged QT interval, unless closely monitored by a healthcare provider.
People with a history of movement disorders, such as tardive dyskinesia, should avoid using Seroquel XR.
Use during pregnancy should only be considered if the benefits outweigh the risks. It is not recommended while breastfeeding, as it can pass into breast milk.
