Zyprexa (Olanzapine)

Brand Options

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Brand Name : Zyprexa

Marketing Authorization Holder : Eli Lilly

Prescription Required

 
 

Generic Option

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Generic Name : Olanzapine

Manufactured By : Authorized UK Generic

Prescription Required

 
 

Product Details

Zyprexa

Information about Zyprexa (Olanzapine)

Zyprexa (Olanzapine) is an atypical antipsychotic medication used primarily for the treatment of schizophrenia, bipolar disorder, and in some cases, as an adjunctive treatment for depression. It works by affecting certain neurotransmitters in the brain, particularly dopamine and serotonin, to help manage the symptoms of these psychiatric disorders.

Product Highlights

  • Zyprexa is used to treat schizophrenia, a condition characterized by symptoms such as delusions, hallucinations, and cognitive disturbances.
  • It is used to manage manic and mixed episodes of bipolar disorder, as well as to prevent recurrence of mood episodes.
  • Zyprexa is sometimes used in combination with other medications to treat major depressive disorder when other antidepressants have been ineffective.
  • Zyprexa can be used in the short-term management of agitation in patients with psychiatric conditions, such as schizophrenia or bipolar disorder.

Key Ingredient

  • Olanzapine

Key Benefits

  • Zyprexa is highly effective in reducing symptoms of psychosis such as delusions, hallucinations, and disorganized thinking associated with schizophrenia.
  • It helps stabilize mood and reduces manic episodes in individuals with bipolar disorder.
  • When used in combination with antidepressants, Zyprexa can help improve symptoms of treatment-resistant depression.
  • It works relatively quickly to address symptoms of agitation or mania in individuals with psychiatric disorders.

Direction of Use

  • The usual starting dose for schizophrenia or bipolar disorder is 5-10 mg daily, depending on individual needs. The dose may be adjusted based on the patient's response to the medication.
  • Zyprexa can be taken with or without food, but it should be taken at the same time each day for the best effect. The orally disintegrating tablets should be taken by placing the tablet directly on the tongue and allowing it to dissolve.
  • In cases of acute agitation or severe symptoms, Zyprexa may be given as an intramuscular injection under the supervision of a healthcare provider.
  • Dosage may be adjusted based on clinical response and side effects.

Safety Concerns

  • Zyprexa is associated with significant weight gain, which may increase the risk of developing metabolic conditions like diabetes and high cholesterol.
  • Olanzapine can lead to changes in glucose metabolism, increasing the risk of diabetes, and lipid changes, which may lead to high cholesterol levels.
  • Zyprexa may cause drowsiness, particularly when starting treatment or adjusting doses, which could impact daily activities.
  • Although less common than with typical antipsychotics, Zyprexa can cause movement-related side effects such as tremors or stiffness.
  • Long-term use of antipsychotics, including Zyprexa, can sometimes lead to tardive dyskinesia, a condition characterized by involuntary movements.
  • A rare but serious condition that can occur with antipsychotics, including Zyprexa. Symptoms include elevated fever, muscle stiffness, changes in mental status, and problems with autonomic functions. 

Avoid Zyprexa (Olanzapine) If

  • If you have a known allergy to olanzapine or any of its ingredients, avoid using Zyprexa.
  • Zyprexa should not be used in individuals with severe liver impairment without medical supervision.
  • Zyprexa should be avoided in elderly patients with dementia-related psychosis because it may increase the risk of death. 
  • Zyprexa can cause sedation and may worsen symptoms in individuals with narrow-angle glaucoma or urinary retention issues.
  • Zyprexa should only be used during pregnancy if the benefits outweigh the risks, and it is not recommended during breastfeeding due to potential adverse effects on the baby.


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