Depakene is a prescription medication primarily used as an anticonvulsant and mood stabilizer. It is commonly used to manage seizure disorders and bipolar disorder. Valproic acid, the active ingredient in Depakene, helps to stabilize electrical activity in the brain and has effects on neurotransmitter systems.
Product Highlights
Managing various types of seizures, including generalized tonic-clonic, complex partial, and absence seizures.
Stabilizing mood in individuals with bipolar disorder, particularly during manic episodes.
Sometimes used off-label to prevent migraines.
Key Ingredient
Valproic Acid
Key Benefits
Helps reduce the frequency and severity of seizures in epilepsy.
Assists in managing mood swings and stabilizing mood in bipolar disorder.
Can help reduce the frequency of migraine attacks (off-label use).
Direction of Use
The dosage varies depending on the condition being treated and patient-specific factors. Typical starting doses range from 10 to 15 mg/kg/day, which may be adjusted based on clinical response and blood levels.
Take Depakene orally with or without food. Capsules should be swallowed whole, and the liquid form should be measured carefully using the provided dosing device.
The following Table is a guide for the initial daily dose of Depakene (valproic acid) (15 mg/kg/day):
Initial Daily Dose
Weight
Total Daily Dose
Number of Capsules or Teaspoonfuls of Syrup
(Kg)
(Lb)
(mg)
Dose 1
Dose 2
Dose 3
10 - 24.9
22 - 54.9
250
0
0
1
25 - 39.9
55 - 87.9
500
1
0
1
40 - 59.9
88 - 131.9
750
1
1
1
60 - 74.9
132 - 164.9
1,000
1
1
2
75 - 89.9
165 - 197.9
1,250
2
1
2
Safety Concerns
May include nausea, drowsiness, dizziness, and weight gain. Gastrointestinal upset and tremors are also possible.
Risk of liver toxicity, pancreatitis, and teratogenic effects (potential to cause birth defects).
Regular monitoring of liver function, blood levels of valproic acid, and complete blood counts is recommended.
Avoid Depakene (Valproic Acid) If
You have a known hypersensitivity to Valproic Acid or any of its components.
Avoid use if you have severe liver impairment or active liver disease due to the risk of liver toxicity.
Valproic Acid is associated with a high risk of birth defects and should be avoided during pregnancy unless absolutely necessary and prescribed by a healthcare provider.
Avoid use if you have a history of pancreatitis or significant pancreatic issues.
