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Information about Sabril (Vigabatrin)
Sabril, known by its generic name Vigabatrin, is an anticonvulsant medication primarily used to treat specific types of epilepsy, particularly in patients who have not responded well to other treatments. It works by inhibiting the enzyme GABA transaminase, thereby increasing the levels of gamma-aminobutyric acid (GABA) in the brain, which helps control seizures.
Product Highlights
- Sabril is used for adults and children with epilepsy whose partial seizures are not adequately controlled by other antiepileptic drugs.
- It is used in children aged 1 month to 2 years with infantile spasms, a condition that causes sudden muscle spasms, often in the first few months of life.
Key Ingredient
Key Benefit
- Especially helpful for patients with drug-resistant complex partial seizures and those experiencing infantile spasms.
- It can be used alone or in combination with other anticonvulsant medications.
- Vigabatrin's unique mechanism of action (increasing GABA levels) makes it an effective treatment option when other drugs fail.
Direction of Use
- The dosage usually begins at a lower level and is gradually increased depending on the patient's response. It is taken by mouth, either in the form of tablets or powder that can be mixed with liquid.
- In infants, the dosage is carefully adjusted based on weight and clinical response.
The exact dosage and administration schedule are prescribed by the healthcare provider, as they depend on the individual condition being treated.
Safety Concerns
- One of the most serious side effects associated with Sabril is irreversible vision loss. Regular eye exams are necessary during treatment to monitor for any visual changes.
- Vigabatrin may cause mood changes, depression, or aggressive behavior, especially in adults.
- Patients may experience drowsiness, memory problems, or other cognitive side effects.
- As with many antiepileptic drugs, there is a potential for suicidal thoughts or behavior, and patients should be monitored for any signs of depression or suicidal ideation.
- Vigabatrin may interact with other medications, including those used to treat epilepsy or depression, and may require adjustments.
Avoid Sabril (Vigabatrin) If
- Patients with a history of severe eye conditions, particularly those affecting vision, should avoid Sabril due to the risk of vision loss.
- Anyone with a known allergy or hypersensitivity to vigabatrin should not take Sabril.
- Given the risk of mood changes, depression, and other psychiatric issues, Sabril should be avoided in individuals with a history of severe psychiatric disorders.
- Sabril should only be used in pregnancy if the benefits outweigh the risks, and it is generally not recommended for breastfeeding unless deemed absolutely necessary.
