Xadago (Safinamide Mesylate)

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Xadago in Europe is manufactured at the following two sites:Catalent Germany Schorndorf GmbH Steinbeisstrasse 2 D- 73614 Schorndorf Germany Zambon S.p.A. Via della Chimica, 9 36100 Vicenza Italy

Prescription Xadago is taken to treat adults with PD (Parkinson's disease) with "off episodes" along with levodopa/carbidopa therapy. When Xadago is taken with levodopa/carbidopa, it helps control PD motor symptoms to improve speach and facial expression, lessen shaking, stiffness and slow movement, and improve balance.

Xadago works in the body to help block MAO-B from breaking down dopamine. Dopamine in your brain is important as too little dopamine can cause PD symptoms. Patients taking Xadago often see improvement in the ability to move and live normally withint 2 to 4 weeks.

Xadago is a once daily oral therapy (tablet) taken at the same time each day with or without food.  Most people taking Xadago can start and stay on the initial dose of 50mg daily as an add on to levodopa/carbidopa. Some patients may need a higher dose of 100mg daily.  Your physician will direct your Xadago dose.

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Information about Xadago (Safinamide Mesylate)

Xadago is an oral medication that contains safinamide mesylate as its active ingredient. It works by increasing dopamine levels in the brain, a neurotransmitter that is often deficient in patients with Parkinson's disease. Xadago can be used as a monotherapy or in combination with levodopa and other Parkinson's medications.

Product Highlights

• Xadago is indicated as an adjunctive treatment for patients with Parkinson's disease, particularly in those experiencing motor fluctuations while on stable doses of levodopa.
• It may also be used alone in patients who cannot tolerate or are not responding well to other Parkinson's treatments.

Key Ingredient

• Safinamide Mesylate

Key Benefits

• Xadago helps reduce motor fluctuations such as "off" periods (when levodopa is not working well), improving overall motor control in Parkinson's patients.
• By inhibiting the breakdown of dopamine and enhancing its release, Xadago helps sustain dopaminergic activity in the brain.
• The convenience of a once-daily dose helps improve patient adherence to the treatment regimen.
• When used alongside levodopa, Xadago can help smooth out fluctuations in response to levodopa and improve overall symptom control.

Direction of Use

• The usual starting dose is 50 mg once daily, and the dose can be increased to 100 mg once daily, depending on the patient’s response and tolerance. Always follow the prescribing doctor's instructions.
• Xadago is taken orally with or without food. It is essential to take it exactly as directed. 
• If you forget a dose, take it as soon as you recall, unless it's almost time for your next dose. Do not take two doses to make up for a missed dose. 

Safety Concerns

• Common side effects may include insomnia, dizziness, nausea, headache, and fatigue. Some patients may also experience changes in mood or behavior.
• Xadago can increase the risk of serotonin syndrome when used with other serotonergic drugs (e.g., certain antidepressants). Symptoms of serotonin syndrome include agitation, hallucinations, rapid heartbeat, fluctuating blood pressure, and increased body temperature.
• Some patients taking Xadago may develop impulse control disorders, such as compulsive gambling, eating, or shopping.
• In rare cases, Xadago may lead to an increase in blood pressure, especially at higher doses. Blood pressure should be monitored regularly.
• Xadago is metabolized by the liver, so patients with liver disease may require dose adjustments.

Avoid Xadago (Safinamide Mesylate) If

• If you are allergic to safinamide or any of its ingredients.
• Patients with severe liver disease should not take Xadago, as it can affect the liver's ability to process the medication.
• Xadago should not be used with other MAO inhibitors or certain antidepressants (such as SSRIs, SNRIs, or tricyclic antidepressants) due to the risk of serotonin syndrome.
• Patients with a history of severe cardiovascular conditions, such as uncontrolled hypertension or heart disease, should avoid using Xadago without careful monitoring.
• Xadago should only be used during pregnancy or while breastfeeding if the benefits outweigh the potential risks. Always consult with your doctor if you are pregnant or planning to become pregnant.