Rebif (Interferon beta 1a)

In the United Kingdom, Rebif is most often given as the RebiDose ready to use injector pen. We suggest this version as it has very positive consumer response,

Prescription Rebif contains interferon beta-1a used in the treatment of relapsing multiple sclerosis where the patient has periods of attacks between periods without symptoms. Rebif is also used by patients who have had only one single attack of demyelination with inflammation and when a patient seems at high risk of developing multiple sclerosis. Rebif is not used in patients with secondary progressive multiple sclerosis that is not relapsing.

Rebif works the same way as natural interferon beta, which acts to reduce inflammation and immune response that attacks the body's mylin.

Rebif is started by a specialist in multiple sclerosis usually with a titrated dose increased until the standard of Rebif is reached. This is done to reduce side effects of Rebif. The standard Rebif dose is 44 mcg delivered by injection under the skin however the lower dose of 22 mcg is given to those who cannot tolerate the higher dose. Patients must be assessed at least every 2 years for progress.

The Refib RebiDose is an electronic injection device used to deliver the exact doses of Rebif required by your doctor. Rebif is meant to be self-injected under the skin after proper training has been given. Refib RebiDose is a single use injector which comes with full instructions which should be studied and followed carefully. There is no assembly required with the RebiDose and it is completely portable.

Refib is shipped and stored in refrigerated conditions (never frozen) and kept from light.

When traveling, patients may remove Refib from the refrigerator for a single period of not more than 14 days, after which it must be returned to the refrigerator.

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Information about Rebif (Interferon beta-1a)

Rebif is a prescription medication that contains interferon beta-1a, a type of protein that helps modulate the immune system. It is used primarily for the treatment of multiple sclerosis (MS), particularly relapsing forms of MS. Interferon beta-1a works by reducing the frequency of MS flare-ups and slowing the progression of physical disability in people with relapsing-remitting MS. Rebif is administered via subcutaneous injection, typically three times a week.

Product Highlights

• Rebif is approved for the treatment of relapsing forms of multiple sclerosis (MS), including relapsing-remitting MS, to help reduce the frequency and severity of relapses (or flare-ups) and delay disease progression.
• Specifically, Rebif helps to manage relapsing-remitting MS, which is characterized by episodes of neurological symptoms followed by periods of recovery.

Key Ingredient

• Interferon beta-1a

Key Benefits

• Rebif can decrease the frequency of MS relapses, helping to prevent the worsening of symptoms. 
• It may slow the progression of physical disability associated with MS, preserving the patient’s ability to perform daily activities.
• Rebif has been shown to improve long-term outcomes for individuals with relapsing-remitting MS when used consistently over time.
• By managing flare-ups and slowing disease progression, Rebif can improve overall quality of life for those living with MS.

Direction of Use

• Rebif is given as a subcutaneous injection (under the skin). It is typically injected three times a week, with at least one day between doses.
• Typical injection sites are the thighs, abdomen, and upper arms. The injection site should be rotated to reduce irritation.
• The starting dose is usually 8.8 mcg, gradually increasing to 22 mcg or 44 mcg based on the patient's response and tolerance.
• Patients are typically trained to administer the injections themselves at home, although some may receive assistance from a healthcare provider or caregiver.

Safety Concerns

• Redness, swelling, or pain at the injection site are common side effects. Rotate injection sites to minimize these reactions.
• Fever, chills, muscle aches, and fatigue may occur after injections, especially in the early stages of treatment. These symptoms usually lessen over time.
• Rebif can affect liver function, so regular monitoring of liver enzymes is recommended during treatment.
• It may cause blood cell count changes, including low white blood cells (leukopenia), low platelets (thrombocytopenia), and anemia, which require monitoring.
• Rebif has been associated with depression and other mental health side effects, including suicidal thoughts, especially in people with a history of mood disorders.
• Severe allergic reactions (e.g., rash, difficulty breathing) are rare but possible, and medical attention should be sought immediately if any signs of an allergic reaction occur.

Avoid Rebif (Interferon beta-1a) If

• You are allergic to interferon beta-1a or any of the ingredients in the formulation. 
• You have decompensated liver disease or significant liver problems.
• You have a history of depression, suicidal thoughts, or severe psychiatric disorders, as interferon beta-1a may worsen these conditions.
• You are pregnant or planning to become pregnant, unless prescribed by your doctor, as the safety of Rebif during pregnancy has not been fully established.
• You are breastfeeding, as interferon beta-1a can pass into breast milk and may harm the infant.
• You have severe heart conditions (e.g., heart failure), as Rebif can cause or exacerbate heart-related issues.
• You have autoimmune disorders, as Rebif can sometimes exacerbate other autoimmune conditions.

This product requires special packaging to maintain its integrity during the shipping process. DO NOT USE THIS MEDICATION if the attached temperature indicator shows that the medication was exposed to temperatures below 2 degrees or above 8 degrees Celsius, and contact the pharmacy immediately.