Information about Questran (Cholestyramine)
Questran is the brand name for cholestyramine, a medication primarily used to reduce high cholesterol levels. It is classified as a bile acid sequestrant, which works by binding to bile acids in the intestines and preventing their reabsorption. This encourages the liver to produce more bile acids by using up cholesterol, thus lowering cholesterol levels in the bloodstream.
Product Highlights
- It is mainly used to reduce LDL cholesterol levels in individuals with high cholesterol.
- Can help relieve itching in patients with liver disease or bile duct obstruction by binding bile acids in the intestines.
- Used for diarrhea caused by excess bile acids in the colon.
- Adjunctive therapy for other lipid disorders when statins or other treatments are insufficient.
Key Ingredient
Key Benefits
- Cholestyramine reduces LDL cholesterol by increasing the excretion of bile acids, which forces the liver to use cholesterol to make more bile.
- By reducing LDL cholesterol, it helps lower the risk of heart disease and stroke.
- Cholestyramine can help with the symptoms of pruritus in patients with liver disease or bile duct issues.
- By binding bile acids, it can alleviate diarrhea caused by bile acid malabsorption.
Direction of Use
- Powder that must be mixed with water or other liquids (such as juice or soft drink).
- Usually taken 1-2 times daily, depending on the condition being treated. The dosage should be increased gradually to reduce the likelihood of side effects.
- Dissolve the prescribed dose of cholestyramine in 2 to 6 ounces of liquid. The mixture should be consumed immediately. It is commonly taken with meals to enhance its effectiveness.
- It’s important to take cholestyramine regularly, as prescribed by your doctor, and not to skip doses.
Safety Concerns
- Common side effects include constipation, bloating, and indigestion. Taking the medication with plenty of fluids can help reduce these effects.
- Cholestyramine can interfere with the absorption of certain medications (such as warfarin, thyroid hormone, or corticosteroids). It is important to take these medications at separate times, at least 1 hour before or 4-6 hours after taking cholestyramine.
- Cholestyramine can reduce the absorption of vitamins A, D, E, and K, potentially leading to deficiencies over time.
- Cholestyramine should be used with caution in people with a history of gastrointestinal problems (e.g., constipation, obstruction).
- Symptoms of overdose are rare but could include severe constipation or bloating.
Avoid Questran (Cholestyramine) If
- People with a history of gastrointestinal issues such as a blockage or severe constipation should avoid cholestyramine.
- If you have a known allergy to cholestyramine or any other ingredients in the medication, you should not take it.
- Though cholestyramine is generally considered safe during pregnancy, it should only be used if absolutely necessary and under the supervision of a doctor.
- Those with severe liver impairment may be advised against using cholestyramine unless deemed essential by a healthcare provider.
