Zestoretic (Lisinopril / HCTZ)

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Brand Name : Zestoretic

Marketing Authorization Holder : AstraZeneca

Prescription Required

 
 

Generic Option

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Generic Name : Lisinopril / HCTZ

Manufactured By : Authorized UK Generic

Prescription Required

 
 

Product Details

Zestoretic

Information about Zestoretic (Lisinopril / HCTZ)

Zestoretic is a combination medication containing Lisinopril and Hydrochlorothiazide (HCTZ), used to treat high blood pressure (hypertension) and heart failure. Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor, while HCTZ is a thiazide diuretic. This combination helps lower blood pressure by relaxing blood vessels and removing excess fluid from the body. Zestoretic is typically prescribed when a single medication is not enough to manage blood pressure.

Product Highlights

  • Zestoretic is primarily used for the treatment of high blood pressure (hypertension) in adults.
  • Zestoretic can also be prescribed to treat heart failure in patients who are not adequately controlled on monotherapy.
  • It may be used in patients with chronic kidney disease or those at risk for kidney complications due to high blood pressure.

Key Ingredient

  • Lisinopril
  • Hydrochlorothiazide (HCTZ)

Key Benefits

  • Zestoretic combines two different mechanisms to control blood pressure effectively, improving patient compliance by reducing the need for multiple medications.
  • By reducing blood pressure and fluid buildup, Zestoretic can help ease the heart's workload, especially in patients with heart failure.
  • The combination of two medications in a single tablet makes it easier for patients to manage their treatment and adhere to the prescribed regimen.
  • ACE inhibitors like lisinopril can help protect kidney function, especially in patients with hypertension or diabetes.

Direction of Use

  • Zestoretic is typically taken once daily, with or without food, as prescribed by a healthcare provider.
  • The dosage will be determined based on the patient’s blood pressure levels, response to treatment, and other medical conditions.
  • It is important to take Zestoretic at the same time each day to help remember and ensure consistent blood pressure management.

Safety Concerns

  • HCTZ can lead to low potassium, sodium, or magnesium levels in the blood. Regular monitoring of electrolytes is essential.
  • Excessive fluid loss caused by the diuretic effect of HCTZ can result in dehydration or a drop in blood pressure, especially when starting the medication or adjusting the dose.
  • Both lisinopril and HCTZ can affect kidney function. Kidney function should be monitored regularly, especially in patients with pre-existing kidney issues.
  • Lisinopril, like other ACE inhibitors, can cause angioedema (swelling of the face, lips, tongue, or throat), which can be life-threatening. Immediate medical attention is needed if any swelling occurs.
  • A persistent dry cough is a known side effect of lisinopril due to its effect on bradykinin. This can be bothersome and may require discontinuation of the medication.
  • Lisinopril can increase potassium levels in the blood, leading to hyperkalemia, which can be dangerous if not monitored.
  • Zestoretic is contraindicated during pregnancy due to the risk of harm to the fetus, especially in the second and third trimesters.

Avoid Zestoretic (Lisinopril / HCTZ) If

  • You are pregnant or planning to become pregnant (especially during the second or third trimester).
  • You are allergic to ACE inhibitors (such as lisinopril), thiazide diuretics (such as HCTZ), or any of the other ingredients in Zestoretic.
  • You have severe kidney disease or are on dialysis, as the medication may worsen kidney function.
  • You have low blood pressure (hypotension) or are at risk for a significant drop in blood pressure.
  • You have a history of angioedema (swelling of the face, lips, or throat) associated with ACE inhibitors.
  • You are taking aliskiren (a medication used for high blood pressure) and have diabetes or kidney disease.
  • You have a history of severe dehydration, electrolyte imbalances (such as low potassium or sodium), or liver disease.


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