Information about Zestoretic (Lisinopril / HCTZ)
Zestoretic is a combination medication containing Lisinopril and Hydrochlorothiazide (HCTZ), used to treat high blood pressure (hypertension) and heart failure. Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor, while HCTZ is a thiazide diuretic. This combination helps lower blood pressure by relaxing blood vessels and removing excess fluid from the body. Zestoretic is typically prescribed when a single medication is not enough to manage blood pressure.
Product Highlights
- Zestoretic is primarily used for the treatment of high blood pressure (hypertension) in adults.
- Zestoretic can also be prescribed to treat heart failure in patients who are not adequately controlled on monotherapy.
- It may be used in patients with chronic kidney disease or those at risk for kidney complications due to high blood pressure.
Key Ingredient
- Lisinopril
- Hydrochlorothiazide (HCTZ)
Key Benefits
- Zestoretic combines two different mechanisms to control blood pressure effectively, improving patient compliance by reducing the need for multiple medications.
- By reducing blood pressure and fluid buildup, Zestoretic can help ease the heart's workload, especially in patients with heart failure.
- The combination of two medications in a single tablet makes it easier for patients to manage their treatment and adhere to the prescribed regimen.
- ACE inhibitors like lisinopril can help protect kidney function, especially in patients with hypertension or diabetes.
Direction of Use
- Zestoretic is typically taken once daily, with or without food, as prescribed by a healthcare provider.
- The dosage will be determined based on the patient’s blood pressure levels, response to treatment, and other medical conditions.
- It is important to take Zestoretic at the same time each day to help remember and ensure consistent blood pressure management.
Safety Concerns
- HCTZ can lead to low potassium, sodium, or magnesium levels in the blood. Regular monitoring of electrolytes is essential.
- Excessive fluid loss caused by the diuretic effect of HCTZ can result in dehydration or a drop in blood pressure, especially when starting the medication or adjusting the dose.
- Both lisinopril and HCTZ can affect kidney function. Kidney function should be monitored regularly, especially in patients with pre-existing kidney issues.
- Lisinopril, like other ACE inhibitors, can cause angioedema (swelling of the face, lips, tongue, or throat), which can be life-threatening. Immediate medical attention is needed if any swelling occurs.
- A persistent dry cough is a known side effect of lisinopril due to its effect on bradykinin. This can be bothersome and may require discontinuation of the medication.
- Lisinopril can increase potassium levels in the blood, leading to hyperkalemia, which can be dangerous if not monitored.
- Zestoretic is contraindicated during pregnancy due to the risk of harm to the fetus, especially in the second and third trimesters.
Avoid Zestoretic (Lisinopril / HCTZ) If
- You are pregnant or planning to become pregnant (especially during the second or third trimester).
- You are allergic to ACE inhibitors (such as lisinopril), thiazide diuretics (such as HCTZ), or any of the other ingredients in Zestoretic.
- You have severe kidney disease or are on dialysis, as the medication may worsen kidney function.
- You have low blood pressure (hypotension) or are at risk for a significant drop in blood pressure.
- You have a history of angioedema (swelling of the face, lips, or throat) associated with ACE inhibitors.
- You are taking aliskiren (a medication used for high blood pressure) and have diabetes or kidney disease.
- You have a history of severe dehydration, electrolyte imbalances (such as low potassium or sodium), or liver disease.
