Hyzaar (Losartan / HCTZ)

Hyzaar is called Cozaar Compound in Europe.

Information about Hyzaar (Losartan / HCTZ)

Hyzaar is a combination medication that includes losartan, an angiotensin II receptor antagonist, and hydrochlorothiazide (HCTZ), a thiazide diuretic. This combination is used primarily to manage high blood pressure and reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy.

Product Highlights

• Treatment of hypertension (high blood pressure)
• Reduction of the risk of stroke in patients with high blood pressure and left ventricular hypertrophy
• Management of fluid retention in certain conditions 
• Losartan blocks the action of angiotensin II, leading to vasodilation; HCTZ promotes sodium and water excretion, reducing blood volume

Key Ingredient

• An angiotensin II receptor antagonist that promotes relaxation of blood vessels
• A diuretic that helps reduce blood pressure by promoting fluid excretion

Key Benefits

• Combines the benefits of both an antihypertensive and a diuretic for more effective blood pressure control.
• Once-daily dosing improves patient compliance.
• Helps lower the risk of stroke in high-risk patients.

Direction of Use

• Administered orally, with or without food, usually once daily.
• Frequent blood pressure monitoring is crucial to confirm the medication's effectiveness.
• Maintain adequate fluid intake while on this medication to prevent dehydration.

Safety Concerns

• Risk of low potassium (hypokalemia) and other electrolyte disturbances; regular monitoring is recommended.
• Risk of low blood pressure, especially after the first dose; caution is advised.
• May affect renal function; regular checks are advised, particularly in those with preexisting conditions.
• Common side effects that may occur due to blood pressure changes.

Avoid Hyzaar (Losartan / HCTZ) If

• You have a known allergy to losartan, hydrochlorothiazide, or any of the ingredients in the formulation.
• You are pregnant or intending to become pregnant, as it may pose risks to the fetus.
• You are breastfeeding without consulting your healthcare provider.
• You have severe kidney dysfunction or anuria (lack of urine production).