Tribenzor (Olmesartan / Amlodipine / HCTZ)

Tribenzor is called Sevikar HCT in Europe.

Information about Tribenzor (Olmesartan / Amlodipine / HCTZ)

Tribenzor is a prescription medication that combines three active ingredients: Olmesartan, Amlodipine, and Hydrochlorothiazide (HCTZ). It is used to treat hypertension (high blood pressure). The combination of these three medications helps lower blood pressure by acting through different mechanisms to relax blood vessels, reduce fluid buildup, and decrease the overall workload on the heart.

Product Highlights

• It is used for the treatment of high blood pressure in adult patients when a single agent is not sufficient to control blood pressure, or when a combination of these three medications is deemed appropriate by a healthcare provider.

Key Ingredient

• Olmesartan
• Amlodipine
• Hydrochlorothiazide (HCTZ)

Key Benefits

• By combining three medications, Tribenzor provides a more potent and well-rounded approach to managing high blood pressure.
• The once-daily tablet simplifies the management of hypertension, potentially improving patient adherence to treatment.
• The combination of an ARB, a calcium channel blocker, and a diuretic allows for broader control over blood pressure by targeting different pathways involved in regulating blood pressure.
• HCTZ helps reduce the fluid retention that can accompany high blood pressure, further supporting blood pressure reduction.

Direction of Use

• Tribenzor is typically taken once daily, with or without food. The exact dosage will be prescribed by a healthcare provider based on the patient’s blood pressure control needs and response to treatment.
• The tablet should be taken whole with a glass of water. Do not chew, crush, or split the tablet. 
• Take Tribenzor at the same time each day to help remember the dose and maintain consistent blood pressure control.

Safety Concerns

• The diuretic component (HCTZ) may cause low levels of potassium, sodium, or magnesium in the blood, which can lead to serious side effects. Regular monitoring of electrolytes is advised.
• The diuretic can cause excessive fluid loss, potentially leading to dehydration and low blood pressure, especially when starting treatment or increasing the dose.
• Olmesartan and HCTZ can affect kidney function, so kidney function should be monitored during treatment.
• Amlodipine may cause a decrease in heart rate or worsen existing heart conditions in some patients.
• Tribenzor is not recommended during pregnancy, particularly during the second and third trimesters, as it may harm the fetus. It is also unknown if the medication passes into breast milk, so caution is needed during breastfeeding.
• Possible side effects may include dizziness, headache, swelling, fatigue, or gastrointestinal issues.

Avoid Tribenzor (Olmesartan / Amlodipine / HCTZ) If

• You are allergic to Olmesartan, Amlodipine, Hydrochlorothiazide, or any other ingredients in Tribenzor.
• You have severe low blood pressure (hypotension), as Tribenzor may further lower blood pressure.
• You have severe kidney impairment or anuria (inability to produce urine), as Tribenzor may exacerbate kidney problems.
• You are pregnant, particularly during the second and third trimesters, as ARBs like Olmesartan can harm the developing fetus.
• You have severe liver problems, as the medication may worsen liver function.
• You are unable to urinate, due to the diuretic component.
• You have a history of severe allergic reactions to sulfonamides (HCTZ is a sulfonamide derivative) or other medications.