Zinamide (Pyrazinamide)

Brand Options

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Brand Name : Zinamide

Marketing Authorization Holder : Genus Pharma

Prescription Required

 
 

Generic Option

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Generic Name : Pyrazinamide

Manufactured By : Authorized UK Generic

Prescription Required

 
 

Product Details

Zinamide

Information about Zinamide (Pyrazinamide)

Zinamide is a medication containing Pyrazinamide, which is primarily used as part of a combination treatment for tuberculosis (TB). Pyrazinamide is a bactericidal drug that works by inhibiting the growth of Mycobacterium tuberculosis, the bacteria responsible for TB. It is usually administered alongside other anti-TB drugs to prevent the development of drug-resistant strains.

Product Highlights

  • Zinamide is used as part of a multi-drug regimen for the treatment of active pulmonary and extrapulmonary tuberculosis. It helps reduce the bacterial load in the body and shortens the duration of treatment.
  • In some cases, Pyrazinamide may be used in combination with other drugs to treat latent TB infections and prevent progression to active TB.
  • Pyrazinamide is commonly included in the treatment regimen for people who have both TB and HIV, as they are more susceptible to complications and require intensive treatment.

Key Ingredient

  • Pyrazinamide

Key Benefits

  • Pyrazinamide plays a crucial role in treating active tuberculosis by killing the tuberculosis bacteria.
  • When used in combination with other TB drugs, Pyrazinamide helps shorten the length of TB treatment, typically from 9–12 months to 6 months in some cases.
  • Pyrazinamide works synergistically with other anti-TB medications like Rifampin and Isoniazid, helping to achieve better bacterial clearance.
  • It is an essential part of treatment for drug-resistant tuberculosis when the bacteria are not susceptible to other anti-TB drugs.

Direction of Use

  • The typical adult dose for Zinamide is 25 mg/kg of body weight daily. Dosage may vary based on the severity of TB, weight, and other health factors.
  • The tablets should be taken orally with a full glass of water. It can be taken regardless of food. 
  • If you miss a dose, take it as soon as you remember, unless it's nearly time for your next dose. Do not take more than the prescribed amount to make up for a missed dose. 
  • Zinamide is typically used as part of a combination therapy for 6 months or longer, depending on the patient’s condition and the TB strain.

Safety Concerns

  • Pyrazinamide can cause liver damage, which can be severe. It is important to monitor liver function regularly during treatment, especially in patients with pre-existing liver conditions.
  • Pyrazinamide can increase uric acid levels in the blood, which may lead to gout or joint pain.
  • Some individuals may experience skin rashes or other allergic reactions. If severe reactions occur, stop using the medication and seek advice from a healthcare provider. 
  • Zinamide should be used during pregnancy only if absolutely necessary, as it may harm the fetus. Pregnant women should consult their doctor before starting treatment.
  • In rare cases, Zinamide may cause hearing loss, especially when used with other TB drugs that affect hearing, like Aminoglycosides.
  • Pyrazinamide should be used with caution in individuals with kidney issues, as it may exacerbate renal problems. Kidney function should be monitored during treatment.

Avoid Zinamide (Pyrazinamide) If

  • Do not use Zinamide if you are allergic to Pyrazinamide or any other components of the medication.
  • If you have severe liver disease (such as cirrhosis or hepatitis), avoid using Zinamide, as it can worsen liver function.
  • Avoid Zinamide if you have gout, as it can increase uric acid levels and exacerbate joint pain.
  • Zinamide should be avoided during pregnancy unless absolutely necessary. Consult your healthcare provider if you are pregnant or planning to become pregnant. 
  • Use Zinamide cautiously in patients with kidney disease, as it may worsen renal function.
  • Alcohol consumption should be limited during treatment with Zinamide due to the risk of liver toxicity.


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