Information about Zinamide (Pyrazinamide)
Zinamide is a medication containing Pyrazinamide, which is primarily used as part of a combination treatment for tuberculosis (TB). Pyrazinamide is a bactericidal drug that works by inhibiting the growth of Mycobacterium tuberculosis, the bacteria responsible for TB. It is usually administered alongside other anti-TB drugs to prevent the development of drug-resistant strains.
Product Highlights
- Zinamide is used as part of a multi-drug regimen for the treatment of active pulmonary and extrapulmonary tuberculosis. It helps reduce the bacterial load in the body and shortens the duration of treatment.
- In some cases, Pyrazinamide may be used in combination with other drugs to treat latent TB infections and prevent progression to active TB.
- Pyrazinamide is commonly included in the treatment regimen for people who have both TB and HIV, as they are more susceptible to complications and require intensive treatment.
Key Ingredient
Key Benefits
- Pyrazinamide plays a crucial role in treating active tuberculosis by killing the tuberculosis bacteria.
- When used in combination with other TB drugs, Pyrazinamide helps shorten the length of TB treatment, typically from 9–12 months to 6 months in some cases.
- Pyrazinamide works synergistically with other anti-TB medications like Rifampin and Isoniazid, helping to achieve better bacterial clearance.
- It is an essential part of treatment for drug-resistant tuberculosis when the bacteria are not susceptible to other anti-TB drugs.
Direction of Use
- The typical adult dose for Zinamide is 25 mg/kg of body weight daily. Dosage may vary based on the severity of TB, weight, and other health factors.
- The tablets should be taken orally with a full glass of water. It can be taken regardless of food.
- If you miss a dose, take it as soon as you remember, unless it's nearly time for your next dose. Do not take more than the prescribed amount to make up for a missed dose.
- Zinamide is typically used as part of a combination therapy for 6 months or longer, depending on the patient’s condition and the TB strain.
Safety Concerns
- Pyrazinamide can cause liver damage, which can be severe. It is important to monitor liver function regularly during treatment, especially in patients with pre-existing liver conditions.
- Pyrazinamide can increase uric acid levels in the blood, which may lead to gout or joint pain.
- Some individuals may experience skin rashes or other allergic reactions. If severe reactions occur, stop using the medication and seek advice from a healthcare provider.
- Zinamide should be used during pregnancy only if absolutely necessary, as it may harm the fetus. Pregnant women should consult their doctor before starting treatment.
- In rare cases, Zinamide may cause hearing loss, especially when used with other TB drugs that affect hearing, like Aminoglycosides.
- Pyrazinamide should be used with caution in individuals with kidney issues, as it may exacerbate renal problems. Kidney function should be monitored during treatment.
Avoid Zinamide (Pyrazinamide) If
- Do not use Zinamide if you are allergic to Pyrazinamide or any other components of the medication.
- If you have severe liver disease (such as cirrhosis or hepatitis), avoid using Zinamide, as it can worsen liver function.
- Avoid Zinamide if you have gout, as it can increase uric acid levels and exacerbate joint pain.
- Zinamide should be avoided during pregnancy unless absolutely necessary. Consult your healthcare provider if you are pregnant or planning to become pregnant.
- Use Zinamide cautiously in patients with kidney disease, as it may worsen renal function.
- Alcohol consumption should be limited during treatment with Zinamide due to the risk of liver toxicity.
