Rifamate (Rifampicin / Isoniazid)

In the Europe, Rifamate (rifampicin / isoniazid) is called Rifinah. Both brands are the same medicine and both are made by Sanofi.

Prescription Rifamate is available for adults in the dose of 300mg/150mg. The 2 medicines combined in Rifamate are anti-tuberculous drugs which kill the bacteria causing tuberculosis. Rifamate is used in all forms of tuberculosis. Rifamate can be taken with other similar medicines.

Use Rifamate exactly as prescribed by your doctor, do not skip doses.There are many possible drug interactions with Rifamate so be cautious and speak with your doctor about all the medicines, vitamins, herbs and antacids that you may be taking.

The standard Rifamate dose is given as a single dose therapy on an empty stomach.

Be advised not to eat food that is high in tyramine and or histamine while taking Rifamate. This includes mature cheeses, cured meat, wine, beer and certain fish.

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Information about Rifamate (Rifampicin / Isoniazid)

Rifamate is a combination medication that contains two active ingredients, rifampicin and isoniazid, both of which are used to treat tuberculosis (TB). The combination of these two drugs helps effectively kill the bacteria responsible for TB and prevent resistance, making it a key component in TB treatment regimens. Rifamate is typically prescribed as part of a multi-drug regimen for the treatment of active tuberculosis and for prevention in individuals at high risk of developing TB.

Product Highlights

• Rifamate is used to treat both active pulmonary and extrapulmonary tuberculosis caused by Mycobacterium tuberculosis. 
• It is used to prevent the development of active TB in individuals with latent TB infection, reducing the risk of progression to active disease.
• Rifamate is also used for preventive treatment in individuals exposed to TB or at high risk for infection, particularly in close contact situations.

Key Ingredient

• Rifampicin
• Isoniazid

Key Benefits

• The combination of rifampicin and isoniazid is highly effective in treating active TB infections and preventing drug resistance.
• Rifamate helps reduce the risk of latent TB progressing to active TB, which can be contagious and more difficult to treat.
• By using both medications together, Rifamate reduces the likelihood of TB bacteria becoming resistant to either drug when used alone.
• Combining two medications into a single tablet simplifies the treatment regimen for patients, improving adherence.

Direction of Use

• The typical dosage is one tablet daily, containing both rifampicin (10 mg/kg) and isoniazid (5 mg/kg), as directed by a healthcare provider.
• Pediatric dosages are determined based on the child's weight and the severity of the infection. Always adhere to the dosing instructions given by your healthcare provider. 
• Rifamate should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal to ensure optimal absorption.
• The length of treatment varies depending on the type of TB being treated but typically lasts for 6 to 9 months. It is crucial to complete the full course to prevent relapse and resistance.

Safety Concerns

• Both rifampicin and isoniazid can cause liver damage, so liver function should be closely monitored during treatment. Regular blood tests might be necessary to monitor liver function. 
• Isoniazid can cause nerve damage, leading to symptoms such as tingling or numbness, especially in patients with vitamin B6 deficiency.
• Rifamate can interact with a wide range of medications, including antiretrovirals (HIV drugs), anticoagulants, and anticonvulsants, potentially reducing their effectiveness or causing harmful side effects. Close monitoring and potential dose adjustments may be required. 
• Common side effects may include nausea, vomiting, and pain. These side effects can be minimized by taking the medication with food if necessary, but this may affect absorption.
• Rifampicin can cause bodily fluids, such as urine, sweat, and tears, to turn an orange or red color, which is harmless but may stain clothing and contact lenses.
• Rare but serious allergic reactions, including rash, fever, and difficulty breathing, can occur. Seek immediate medical attention if these symptoms occur. 

Avoid Rifamate (Rifampicin / Isoniazid) If

• Individuals with a known allergy to rifampicin, isoniazid, or any other components of Rifamate should not take this medication.
• Rifamate should not be used in patients with active liver disease (e.g., hepatitis or cirrhosis) due to the risk of further liver damage.
• If you have experienced severe reactions to either rifampicin or isoniazid in the past, it is important to avoid this combination therapy.
• Rifamate should only be used during pregnancy if the benefits outweigh the potential risks. It is classified as pregnancy category C, meaning it should be used under strict medical supervision if prescribed.
• Rifampicin and isoniazid are excreted in breast milk. If you are breastfeeding, discuss with your doctor whether this treatment is appropriate for you.
• Alcohol use can increase the risk of liver toxicity when taking Rifamate. Limit or avoid alcohol consumption during treatment.