Prescription Rifater is a combination of 3 medicines: isoniazid, rifampicin and pyrazinamide. Theses drugs work together to kill the tuberculosis bacteria in the lungs. Only adults should take Rifater.
Rifater is taken on an empty stomach, usually once daily (usually between 3 and 6 tablets) as per the physicians prescription. Swallow Rifater whole with an 8 oz glass of water. Avoid antacids for 1 hour before taking Rifater.
Because Rifater is treating an infection, it must be taken for the entire length of time prescribed by the doctor, even if you feel well. Ask your physician if you should also supplement your diet with vitamin B6 during treatment.
While taking Rifater, avoid foods high in histamine and tyramine including mature cheese, beer, wine, cured meat and some types of fish.
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Information about Rifater (Rifampicin / Isoniazid / Pyrazinamide)
Rifater is a combination medication used primarily in the treatment of tuberculosis (TB). It contains three active ingredients: Rifampicin, Isoniazid, and Pyrazinamide. These medications work together to kill the bacteria that cause TB by targeting different mechanisms in the bacteria's life cycle. This combination is often used in the initial phase of TB treatment to reduce the risk of developing drug resistance and improve treatment outcomes.
Product Highlights
- Rifater is used to treat active tuberculosis caused by Mycobacterium tuberculosis in adults and children over 12 years of age.
- It is used in the initial phase of treatment, typically for the first 2 months, as part of a comprehensive TB therapy regimen that includes other medications.
Key Ingredients
- An antibiotic that inhibits bacterial RNA synthesis, leading to the death of the TB bacteria.
- An antimicrobial agent that inhibits the synthesis of mycolic acid, a component of the bacterial cell wall, and disrupts bacterial growth.
- A bactericidal agent that works by lowering the pH inside the bacterial cell, making it more acidic and inhibiting bacterial growth.
Key Benefits
- The combination of Rifampicin, Isoniazid, and Pyrazinamide offers a potent approach to treat active TB by acting on different targets within the bacteria.
- By combining multiple drugs with different mechanisms of action, Rifater helps reduce the likelihood of the bacteria developing resistance to the treatment.
- Instead of taking multiple pills, Rifater offers a convenient single-pill combination for better patient adherence.
- The combination therapy accelerates the treatment process by effectively attacking the bacteria from multiple angles.
Direction of Use
- Rifater is typically taken once daily under the supervision of a healthcare provider. The dosage may vary depending on the patient's weight and the severity of the tuberculosis infection.
- It is recommended to be taken on an empty stomach (1 hour before or 2 hours after meals) for optimal absorption.
- Rifater is usually given in the intensive phase of TB treatment, which lasts for 2 months, followed by continuation therapy with other TB medications.
Safety Concerns
- One of the primary safety concerns with Rifater is the potential for liver damage. Regular monitoring of liver function is advised during treatment, as all three drugs can cause hepatic toxicity.
- Rifampicin can interfere with other medications, including certain anti-HIV drugs, anticoagulants, and birth control pills, reducing their effectiveness.
- Isoniazid can cause nerve damage (peripheral neuropathy), especially in patients who are malnourished or have diabetes. Vitamin B6 supplementation is often recommended to prevent this.
- Common side effects may include nausea, vomiting, fever, rash, and stomach upset. Serious side effects include jaundice, allergic reactions, or signs of severe liver injury.
- Rifater should be used with caution in pregnant or breastfeeding women and only if the benefits outweigh the risks, as some of the components may harm the fetus or infant.
Avoid Rifater (Rifampicin / Isoniazid / Pyrazinamide) If
- Patients with pre-existing liver conditions (such as hepatitis or cirrhosis) should avoid Rifater due to the risk of further liver damage.
- Individuals with known hypersensitivity to any of the active ingredients in Rifater (Rifampicin, Isoniazid, Pyrazinamide) should not use this medication.
- Rifater should be avoided during the first trimester of pregnancy unless absolutely necessary, as the risk to the fetus may outweigh the benefits.
- Those with severe kidney impairment may need an alternative treatment or special dosing adjustments.
- Patients who consume alcohol regularly may be at increased risk of liver toxicity and should avoid using Rifater or use it under strict medical supervision.
