Sivextro (Tedizolid) is an antibiotic that treats specific bacterial infections and is classified under oxazolidinones. Tedizolid works by inhibiting the growth of bacteria, helping to treat infections caused by various types of resistant organisms, including Staphylococcus aureus (including methicillin-resistant strains, MRSA) and Streptococcus species.
Product Highlights
Used in the treatment of infections like cellulitis, abscesses, and wound infections caused by susceptible organisms such as MRSA and other Gram-positive bacteria.
Effective for infections caused by resistant strains of bacteria, including multidrug-resistant Staphylococcus aureus (MRSA).
It is generally considered when other treatment options may not be effective, such as in cases of resistance to common antibiotics.
Key Ingredient
Tedizolid Phosphate
Key Benefits
Particularly effective in treating MRSA infections, which are resistant to many other antibiotics.
Typically administered once daily, which is an advantage for patient compliance.
A typical course lasts 6 days, which is shorter than many other antibiotics for similar indications.
Compared to other antibiotics, it may have a more favorable side-effect profile, especially in terms of gastrointestinal issues or blood-related side effects.
Direction of Use
Typically taken once daily, with or without food.
Given via an intravenous infusion by healthcare professionals, typically once a day.
It’s important to follow the prescribed duration of treatment to ensure the infection is fully eradicated and to avoid resistance development.
The typical treatment duration for ABSSSI is 6 days.
Dosage of SIVEXTRO
Infection
Route
Dosage
Frequency
Infusion Time
Duration of Treatment
Acute Bacterial Skin and Skin Structure Infections (ABSSSI)
Intravenous
200 mg
Once daily
1 hour
6 days
Oral
200 mg
Once daily
Not Applicable
Safety Concerns
Common side effects may include diarrhea, nausea, headaches, and vomiting. More serious side effects could include thrombocytopenia (low platelet count) and bone marrow suppression.
Regular blood tests may be needed to monitor for any impact on blood cell counts, particularly in patients with prolonged use or underlying conditions.
There is a potential for interactions with other drugs, particularly those that affect serotonin levels in the body.
Avoid Sivextro (Tedizolid) If
If you are allergic to tedizolid or any of the ingredients in Sivextro.
It should be avoided in combination with certain medications that affect serotonin levels (such as selective serotonin reuptake inhibitors (SSRIs)) due to the potential risk of serotonin syndrome, a serious condition that can cause high fever, agitation, and seizures.
While animal studies have not shown direct harm, the safety of Sivextro during pregnancy and breastfeeding is not fully established. It should only be used when clearly necessary and prescribed by a healthcare provider.
In cases of severe kidney disease, the drug should be used cautiously or avoided as dosing adjustments may be necessary.
