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In the United Kingdom, Xenazine (tetrabenazine) brand was recently discontinued and now the generic Xenazine is available as scored 25mg tablets. Although 12.5mg is not available in the United Kingdom, the 25mg is easily split as it is scored to deliver 12.5mg when that dose is required.
Prescription Xenazine and its generic equivalent are used in adults to treat conditions prescribed by your physician. Xenazine is primarily taken in the treatment of Huntington's disease (uncontrolled movements of muscles). Xenazine is not a cure and is not useful in other symptoms of Huntington's disease such as difficulties thinking or problems with emotion.
Adults taking generic Xenazine for Huntington's chorea are each dosed differently depending on the individual results and requirements of each patient. The standard Xenazine dose when beginning treatment is 12.5mg (half tablet of 25mg) from 1 to 3 times daily. This Xenazine dose can be increased every 3 or 4 days until the optimal effect occurs or until side effects such as sedation, Parkinsonism or depression occur. The maximum dose of generic Xenazine is 200mg each day. If Xenazine is not effective after 1 week of the maximum dose, it may be better to withdraw the drug.
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Information about Xenazine (Tetrabenazine)
Xenazine contains tetrabenazine, which is a drug that works by depleting dopamine in the brain. Dopamine is a neurotransmitter involved in muscle control and movement. By reducing dopamine levels, Xenazine helps to control involuntary movements (chorea) and improve motor function in conditions like Huntington's disease. It is taken orally and works by affecting the central nervous system.
Product Highlights
- Xenazine is primarily used to treat chorea (involuntary, jerky movements) linked to Huntington's disease.
- Xenazine may be used off-label to treat tardive dyskinesia, a condition characterized by repetitive, involuntary movements caused by long-term use of antipsychotic medications.
- It may also be used in the treatment of other conditions involving involuntary muscle movements, as determined by the healthcare provider.
Key Ingredient
Key Benefits
- Xenazine is effective at reducing chorea and other involuntary movements, improving the quality of life for patients with movement disorders.
- By regulating dopamine levels, Xenazine can enhance motor control and reduce the impact of erratic muscle movements.
- Xenazine is designed specifically to target the underlying cause of movement disorders, making it a more focused treatment option compared to other medications.
- It helps patients with conditions such as Huntington's disease to better manage symptoms and maintain function.
Direction of Use
- The starting dose for Xenazine is typically 12.5 mg once or twice daily, with the dose gradually increased depending on patient tolerance and response. The maximum recommended dose is 50 mg per day.
- Xenazine should be taken by mouth, with or without food. Follow your healthcare provider’s directions regarding dosage adjustments and timing.
- If you miss a dose, take it as soon as you recall, unless it's almost time for your next dose. Do not take two doses to compensate for the missed one.
- Try to take Xenazine at the same time every day to help remember and maintain a consistent level of the medication in your body.
Safety Concerns
- Xenazine can cause sedation and drowsiness. Patients should use caution when engaging in activities that require full alertness, such as driving or operating machinery.
- Xenazine has been linked to a higher risk of depression and thoughts of suicide. Patients with a history of depression or mental health issues should be monitored closely.
- Xenazine may cause symptoms similar to Parkinson’s disease, such as rigidity and tremors. Any new or unusual symptoms should be communicated to your healthcare provider.
- Patients with liver impairment may require a lower dose, and liver function should be monitored regularly.
- Xenazine can cause QT prolongation (a type of irregular heartbeat) and may increase the risk of arrhythmias, especially in patients with existing heart conditions. Regular heart monitoring is recommended.
- Xenazine may interact with other medications, including antidepressants, antipsychotics, and other CNS-active drugs, which may increase the risk of side effects.
Avoid Xenazine (Tetrabenazine) If
- Do not use Xenazine if you have a known allergy to tetrabenazine or any of its ingredients.
- Xenazine should not be used in patients with severe liver impairment, as it may worsen liver function.
- If you have a history of depression or suicidal thoughts, use Xenazine with extreme caution and under close medical supervision.
- Xenazine should not be used in patients with Parkinson’s disease due to the risk of worsening motor symptoms.
- Avoid Xenazine if you have a history of QT interval prolongation or other heart conditions that may predispose you to arrhythmias.
- Xenazine is not recommended during pregnancy or while breastfeeding, as it may harm the fetus or infant.
