Biktarvy (Tenofovir alafenamide fumarate / Emtricitabine / Bictegravir sodium)

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Manufacturer for EU Bitkarvy: Gilead Sciences Ireland UC IDA Business & Technology Park Carrigtohill County Cork Ireland

Prescription Biktarvy contains 50mg bictegravir, 200mg emtricitabine and 25mg tenofovir alafenamide. Biktarvy interferes with the enzymes integrase and reverse transcriptase which are needed by the HIV virus. Use of Biktarvy reduces the virus ability to replicate itself and infect cells.

The goal of treatment is to bring down the viral load of HIV until it is undetectable in the blood. Bringing down the levels of the virus prevents HIV transmission during sex. Biktarvy can make HIV undetectable in 8 to 24 weeks of treatment when taken as prescribed.

Biktarvy is not taken with other medicines for HIV-1. The combination in Biktarvy is the complete treatment of HIV.

Biktarvy is used by adult patients with HIV-1 who are new to treatment or replacing an existing regimen. Biktarvy is taken once daily with or without food at any time of day (same time each day). Take Biktarvy exactly as prescribed and do not miss a dose.

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Information about Biktarvy

Biktarvy is a medicine used in the treatment of HIV-1 infection. It is a single-tablet regimen that combines three antiretroviral drugs into one convenient daily pill. This combination therapy helps manage HIV-1 infection by inhibiting the replication of the virus.

Biktarvy is used for the treatment of HIV-1 infection in adults and pediatric patients weighing at least 25 kg (55 lbs) who have never been treated before or to replace the current antiretroviral regimen in those who are virologically suppressed.

Biktarvy integrates three active ingredients into one single daily pill, simplifying the treatment regimen for people living with HIV. This combination includes two antiretroviral drugs from different classes: a nucleotide reverse transcriptase inhibitor and an integrase strand transfer inhibitor.

Product Highlights

• Biktarvy is a prescription medication used for the treatment of HIV-1 infection.
• A prodrug of tenofovir, TAF is designed to be more effective and have a lower risk of causing bone and kidney issues compared to its predecessor, Tenofovir disoproxil fumarate (TDF).
• A nucleoside reverse transcriptase inhibitor (NRTI) that helps to prevent HIV from replicating.
• An integrase strand transfer inhibitor (INSTI) that blocks the integration of HIV DNA into the host cell's DNA.

Key Ingredient

• Tenofovir Alafenamide Fumarate (TAF)
• Emtricitabine
• Bictegravir

Key Benefits

• Biktarvy is a once-daily, single-tablet regimen, which can improve adherence to treatment.
• It is highly effective in suppressing HIV viral load to undetectable levels in many patients.
• Compared to some other HIV medications, Biktarvy has a favorable side effect profile, with less impact on bone mineral density and kidney function due to its use of TAF rather than older forms of tenofovir.
• Bictegravir has a high barrier to resistance, meaning it is less likely for the virus to develop resistance to this medication.

Direction of Use

• The standard dose is one tablet taken orally once a day with or without food.
• It’s crucial to take Biktarvy exactly as prescribed and not miss doses to maintain its effectiveness and reduce the risk of developing drug-resistant HIV strains.

Safety Concerns

• Include nausea, diarrhea, headache, and fatigue.
• May involve lactic acidosis, severe liver problems, or changes in bone mineral density. Consistent oversight by a healthcare provider is vital.
• While TAF has less impact on kidney function compared to earlier tenofovir formulations, regular kidney function tests are recommended.

Avoid Biktarvy (Tenofovir alafenamide fumarate / Emtricitabine / Bictegravir sodium) If

• You have a known allergy to any of the ingredients (TAF, emtricitabine, or bictegravir).
• It is not effective for HIV strains that are resistant to one of its components.
• It should be avoided in combination with certain other medications that could interact negatively, such as specific anticonvulsants or some types of antibiotics. Make sure to let your healthcare provider know about all the medications you are taking.
• If you have severe liver impairment or active liver disease, Biktarvy may not be suitable.