Kaletra is a combination medication containing lopinavir and ritonavir, used in the treatment of HIV-1 infection. It works by inhibiting the protease enzyme, essential for viral replication.
Product Highlights
Treatment of HIV-1 infection in adults and pediatric patients as part of an antiretroviral therapy regimen.
Key Ingredient
Lopinavir
Ritonavir
Key Benefits
Helps control viral load, improving immune function in HIV-infected patients.
The combination enhances antiviral activity and reduces the risk of resistance.
Available in both tablet and liquid forms, accommodating different patient needs.
Direction of Use
Take Kaletra exactly as prescribed, usually twice daily.
It can be taken with or without food, but taking it with food may enhance absorption.
Follow specific dosing instructions, especially for the oral solution, which should be measured accurately.
The following table contains dosing guidelines for Kaletra 100/25 mg tablets in children based on body weight, without efavirenz, nevirapine, nelfinavir or amprenavir
Paediatric Dosing Guidelines without Concomitant Efavirenz, Nevirapine or Amprenavir
Body Weight (kg)
Recommended number of 100/25 mg Tablets Twice Daily
Administered Dose
7 to < 10
1
100/25 mg
≥ 10 to < 25
2
200/50 mg
≥ 25 to < 35
3
300/75 mg
≥ 35
4
400/100 m
The following table contains dosing guidelines for Kaletra 100/25 mg tablets in children based on body weight, when used in combination with efavirenz, nevirapine, nelfinavir, or amprenavir
Pediatric Dosing Guidelines for Use with Efavirenz, Nevirapine, or Amprenavir
Body Weight (kg)
Recommended number of 100/25 mg Tablets Twice Daily
Administered Dose
≥ 10 to < 20
2
200/50 mg
≥ 20 to < 30
3
300/75 mg
> 30 kg to 45 kg
4
400/100 mg
> 45 kg
5
500/125 mg
Safety Concerns
Common side effects include diarrhea, nausea, headaches, and stomach discomfort.
Serious side effects can include liver problems, heart rhythm changes, and allergic reactions.
Regular monitoring of liver function and lipid levels is recommended during treatment.
Avoid Kaletra (Lopinavir / Ritonavir) If
You have a known hypersensitivity to lopinavir, ritonavir, or any of its components.
You have severe liver disease or active hepatitis.
You are taking certain medications that may interact adversely, such as certain anticonvulsants and herbal supplements like St. John's Wort.
