Truvada (Emtricitabine / Tenofovir)

Truvada in the United Kingdom is identical to Truvada in the United States. The strength of Truvada is also the same in both countries, however the packaging makes the strength look different. One ingredient in Truvada is Tenofovir, which is listed as 300mg on US packaging but 245mg on UK packaging. The reason for this is that the US measures the weight of the full salt Tenofovir Disoproxil Fumarate while the UK version measures the weight of Tenofovir Disoproxil (without the fumarate salt component). Both Truvada versions are absolutely identical.

Prescription Truvada (emtricitabine and tenofovir disoproxil fumarate) is a for the treatment of HIV-1 infection for people over 77 pounds. Truvada blocks the reverse transcriptase enzyme which is required by the HIV virus to replicate. Blocking this enzyme prevents the HIV virus from spreading in the body and causing further damage to the immune system and additional conditions and infections. Truvada, alongside with other HIV medicines will not cure HIV or AIDS. 

When Truvada is used to treat existing HIV infection, it is always given alongside of other HIV medicines.

A new indication of Truvada is to reduce the risk of getting HIV infections through sex. It must be taken every day alongside of safe sex practices. Find out from your doctor if Truvada for pre-exposure is right for you. Truvada will not prevent other sexually transmitted diseases. Be sure that you are tested negative for HIV before beginning Truvada for this purpose.

The usual dose of Truvada is once per day with or without food, exactly as prescribed. Do not miss doses of Truvada or stop taking Truvada without talking with your physician.

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Information about Truvada (Emtricitabine / Tenofovir)

Truvada is primarily used as part of combination therapy for the treatment of HIV-1 infection. It contains two active ingredients, Emtricitabine and Tenofovir disoproxil fumarate, both of which belong to a class of drugs known as nucleoside reverse transcriptase inhibitors (NRTIs). These medications work by interfering with the replication process of the HIV virus, reducing the amount of virus in the blood and helping to prevent damage to the immune system. Truvada can also be used for pre-exposure prophylaxis (PrEP) to prevent HIV infection in high-risk individuals.

Product Highlights

• Truvada is used as part of a combination antiretroviral regimen for the treatment of HIV-1 infection in adults and children.
• Truvada is prescribed for the prevention of HIV infection in individuals who are at high risk of contracting the virus through sexual contact or injection drug use.
• Truvada may also be part of a post-exposure prophylaxis (PEP) regimen, used in combination with other drugs to prevent HIV infection after potential exposure (e.g., after unprotected sex or needle-sharing).

Key Ingredient

• Emtricitabine
• Tenofovir Disoproxil Fumarate

Key Benefits

• Truvada helps reduce viral load in individuals with HIV, supporting immune function and preventing disease progression when used in combination with other medications.
• As part of a comprehensive prevention strategy, Truvada is highly effective in reducing the risk of HIV infection in high-risk individuals (PrEP).
• Truvada is taken once daily, improving patient adherence and ease of use.
• Both Emtricitabine and Tenofovir have been used in clinical practice for years, offering a strong track record of safety and effectiveness.
• By controlling viral replication, Truvada helps to reduce the risk of complications associated with untreated HIV, such as opportunistic infections and organ damage.

Direction of Use

• The typical dosage for HIV treatment is one tablet of Truvada once a day, in combination with other antiretroviral medications. The dosage for PrEP is also one tablet once a day.
• Take Truvada with or without food, as directed by your healthcare provider. Take the tablet whole without chewing or crushing it. 
• If you miss a dose, take it as soon as possible, unless it's almost time for your next dose. Avoid taking two doses to compensate for a missed dose. 

Safety Concerns

• Truvada can cause kidney problems, including kidney damage. It’s important to monitor kidney function through blood tests during treatment, especially for individuals with pre-existing kidney issues.
• Prolonged use of Truvada may cause bone loss or weaken bones, which may increase the risk of fractures. Bone density monitoring may be necessary for long-term users.
• Although rare, a serious condition called lactic acidosis (buildup of lactic acid in the blood) can occur. Symptoms may include weakness, muscle pain, difficulty breathing, or stomach discomfort.
• Truvada should not be stopped abruptly in people with hepatitis B, as this may lead to a flare-up of the virus.
• Truvada is considered safe for use during pregnancy for HIV treatment, but it should only be used in consultation with a healthcare provider.
• Truvada may cause common side effects such as nausea, diarrhea, headache, and tiredness. If you experience severe side effects like dark urine, yellowing of the skin or eyes, or severe stomach pain, seek medical attention immediately.

Avoid Truvada (Emtricitabine / Tenofovir) If

• You are allergic to Emtricitabine, Tenofovir, or any of the inactive ingredients in Truvada.
• You have severe kidney disease or a history of kidney problems, as Truvada can worsen kidney function.
• You have liver disease, especially if you have hepatitis B, as stopping Truvada may cause a sudden worsening of hepatitis B.
• You are pregnant or breastfeeding, unless directed by your doctor. While Truvada is generally considered safe in pregnancy for treating HIV, it should only be used under a healthcare provider's guidance.
• You have a history of bone problems, as Truvada may affect bone density, and you may need additional monitoring.