Tybost (Cobicistat)

Prescription Tybost contains 150mg cobicistat, is used in the treatment of adults with HIV-1, the virus causing AIDS. Tybost is not used alone but is given to boost the effects of darunavir, atazanavir and tenofovir alafenamide which are standard HIV treatments.

Tybost is given once per day with food. Tybost is often given with 300mg atazanavir or 800mg darunavir. Tybost blocks the enzyme CYP3A which breaks down these medicines (and others). By blocking this enzyme, these medicines remain in the body for a prolonged length of time preventing the HIV virus from spreading or causing further damage.

Because Tybost will block this enzyme, many drugs can be effected in the body, potentially increasing the risk of side effects of those medicines. You may need to adjust your other medicine doses when starting Tybost.

Tybost is not combined with HIV medicines containing cobicistat or ritonavir.

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Information about Tybost (Cobicistat)

Tybost (Cobicistat) is a pharmacokinetic enhancer (also known as a "booster") that is used in combination with other medications to improve the effectiveness of antiretroviral drugs, particularly in the treatment of HIV. Cobicistat works by inhibiting the enzyme cytochrome P450 3A, which normally breaks down other medications in the liver. By inhibiting this enzyme, cobicistat increases the levels of certain drugs in the body, making them more effective.

Product Highlights

• Tybost is used in combination with other antiretroviral medications to treat HIV-1 infection. 
• It is not a standalone treatment for HIV but is included in combination therapy to enhance the effectiveness of other drugs.

Key Ingredient

• Cobicistat

Key Benefits

• By boosting the levels of co-administered drugs, cobicistat helps maintain effective drug concentrations in the body, leading to better control of HIV.
• Tybost is typically taken once a day, making it a convenient option for patients who need to take multiple medications for HIV.
• Tybost itself does not treat HIV directly, but it makes other HIV medications more potent and effective, contributing to overall viral suppression.

Direction of Use

• Tybost is usually taken once daily with food. The typical dosage is 150 mg per day.
• It is important to follow the doctor's instructions regarding how and when to take Tybost, especially when combined with other medications.
• Tybost is generally taken as part of a combination regimen, alongside other antiretroviral drugs, to help manage HIV.

Recommended Dosage in Adults

Safety Concerns

• Cobicistat can interact with many other medications because it inhibits the CYP3A enzyme. These interactions can increase the levels of other drugs, potentially leading to adverse effects. Patients should let their healthcare providers know about all the medications they are currently using. 
• Cobicistat can affect kidney function, particularly in people with preexisting kidney disease, so renal function should be monitored during treatment.
• It can cause liver enzyme abnormalities, so regular liver function tests are advised during therapy.

Avoid Tybost (Cobicistat) If

• Tybost should be avoided in individuals with moderate to severe liver impairment due to the risk of worsening liver function.
• If you have a known allergy to cobicistat or any of the components of Tybost, it should not be used.
• Tybost can interact with many drugs, including certain anticonvulsants, sedatives, and some antibiotics. Always inform your healthcare provider of all medications you are using to avoid harmful interactions.
• It is generally advised to avoid cobicistat in patients with severe renal impairment due to potential kidney-related side effects.