Information about Zerit (Stavudine)
Zerit, the brand name for Stavudine, is an antiviral medication used to treat HIV/AIDS (Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome). It belongs to a class of drugs called nucleoside reverse transcriptase inhibitors (NRTIs), which work by inhibiting reverse transcriptase, an enzyme essential for the replication of the HIV virus. By blocking this enzyme, Stavudine helps prevent the virus from multiplying in the body, reducing the progression of HIV infection.
Product Highlights
- Zerit is used to treat HIV infection in adults and pediatric patients as part of combination therapy. It is not used alone but in combination with other antiretroviral agents.
- It may also be prescribed to prevent the progression of HIV to AIDS by decreasing viral load and enhancing immune function.
Key Ingredient
Key Benefits
- Stavudine effectively slows the replication of HIV in the body, which helps lower viral load and protect the immune system.
- By reducing the viral load, Stavudine allows the immune system to strengthen, helping to prevent further infections and related complications.
- With proper use in combination therapy, Zerit can prevent HIV from progressing to AIDS, improving quality of life and prolonging survival.
- Zerit is available in both oral capsule and liquid formulations, making it easier for patients with different needs (such as children or those who have difficulty swallowing pills) to take their medication.
Direction of Use
- Zerit is usually taken once or twice daily, depending on the prescribed dosage. It can be taken either with or without food.
- The medication is available in capsule form or as an oral solution, which should be measured carefully with a dosing syringe or spoon.
- The exact dosage is determined by the healthcare provider based on the patient's weight, age, and response to treatment. It is important to follow the prescribed regimen and not skip doses to maintain effectiveness.
Safety Concerns
- Stavudine has been associated with the development of peripheral neuropathy, a condition that causes nerve damage, leading to pain, tingling, or numbness in the extremities. This is a serious side effect and should be monitored.
- In rare cases, stavudine can cause lactic acidosis (buildup of lactic acid in the blood), which can be fatal if not treated promptly. Regular monitoring is required to detect early signs.
- Stavudine can cause liver problems, including liver failure, so regular liver function tests are recommended.
- Long-term use of Stavudine has been linked to fat redistribution, leading to changes in body fat (such as fat loss in the face and limbs or fat accumulation in the abdomen).
- Stavudine can cause kidney problems, so kidney function should be monitored during treatment.
- Zerit may interact with other antiretrovirals or medications, which could affect its efficacy or cause unwanted side effects. Inform your healthcare provider about all other medications being taken.
Avoid Zerit (Stavudine) If
- You have a history of liver disease, especially hepatic failure or hepatitis.
- You have a history of pancreatitis or other disorders affecting the pancreas.
- You are allergic to Stavudine or any other ingredients in Zerit.
- You have severe kidney impairment or are undergoing kidney dialysis.
- You have peripheral neuropathy or any history of nerve damage that could be worsened by the drug.
- You are pregnant or breastfeeding, unless the potential benefits outweigh the risks. Stavudine should only be used during pregnancy if absolutely necessary, and it is not recommended during breastfeeding as it can pass into breast milk.
