Nocdurna (Desmopressin)

In Europe, Nocdurna is sold under the trade name Noqdirna. In the USA, the doses listed are 27.2mcg and 55.3mcg desmopressin acetate. In the United kingdom, the doses are listed as 25mcg and 50mcg of desomopressin, The difference in apparent strength is because the USA measures the weight of the full salt, whereas the United Kingdom measures on the active desmopressin component without the salt. Both versions are made by Ferring Pharmaceuticals and are identical in actual strength of active ingredient.

Prescription Nocdurna is an antidiuretic which serves to reduce urine production. Nocdurna is prescribed to adults for the treatment of nocturia (frequent urination at night) due to overproduction of urine. Nocdurna works by imitating the hormone vasopressin which exists naturally in your body. This hormone causes your kidneys to produce less urine while you sleep.

Nocdurna is taken without food or water as a sublingual tablet under your tongue. When taking Nocdurna, first peel the foil at the indicated point in the packaging without pushing the tablet through the foil (as you may break the tablet). Do not take broken tablets, use only full unbroken tablets of Nocdurna. Do not chew or swallow Nocdurna, simply place under your tongue.

Limit the amount of fluid you drink at least 1 hour before taking Nocdurna until 8 hours after your dose. Taken properly before bedtime, Nocdurna dissolves in seconds and begins to work within 30 minutes. Nocdurna has been shown to reduce urination at night by almost half.

The standard Nocdurna dose is 27.2mcg daily one hour before bedtime for women and 55.3mcg daily one hour before bedtime for men.

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Information about Nocdurna (Desmopressin)

Nocdurna is a prescription medication that contains desmopressin, a synthetic analog of the natural hormone vasopressin (also known as antidiuretic hormone or ADH). Desmopressin works by increasing the reabsorption of water in the kidneys, which helps to reduce urine output. Nocdurna is primarily used to treat nocturia (frequent nighttime urination) in adults, particularly those who have a condition called idiopathic nocturia, where frequent urination disrupts sleep. It can also be used for certain other conditions, including diabetes insipidus and bedwetting (enuresis) in children.

Product Highlights

• Nocdurna is used to treat nocturia, a condition where patients have to wake up multiple times during the night to urinate. This condition is commonly seen in older adults and can disrupt sleep, leading to daytime fatigue and other health issues.
• Nocdurna may be used to treat bedwetting in children who are at least 5 years old, particularly those with nocturnal enuresis.
• Desmopressin is also used in the treatment of central diabetes insipidus, a condition where the kidneys cannot concentrate urine due to a lack of vasopressin (the body's antidiuretic hormone).

Key Ingredient

• Desmopressin

Key Benefits

• Nocdurna effectively reduces the frequency of urination at night, helping individuals with nocturia get a more restful night’s sleep.
• By reducing the need to wake up to urinate, Nocdurna helps improve sleep quality and reduces sleep disturbances.
• For children with nocturnal enuresis (bedwetting), Nocdurna can help reduce the frequency of bedwetting episodes.
• In patients with central diabetes insipidus, Nocdurna can help prevent dehydration by reducing excessive urination and increasing urine concentration.
• Generally well-tolerated when used as prescribed, with a low incidence of side effects when taken correctly.

Direction of Use

• The typical starting dose of Nocdurna is 25 mcg, taken once daily at bedtime. Your doctor may change the dose based on your response to the medication.
• For Nocturia: The usual dose is 25 mcg daily taken 1–2 hours before bedtime. The dose may be modified according to your response and tolerance to the medication.
• For Bedwetting: The dose for children is typically 25 mcg or 50 mcg, taken 30 minutes to 1 hour before bedtime, as prescribed by the doctor.
• Take Nocdurna with water on an empty stomach. Do not take with food, as this may affect how the medication works.
• It is important to limit fluid intake in the hours before taking Nocdurna to prevent water intoxication or hyponatremia (low sodium levels in the blood). Your healthcare provider will give you guidance on how much fluid to drink throughout the day.
• If you miss a dose, skip the missed dose and take your next dose at the usual time. Do not take two doses at the same time to compensate for a missed dose.

Safety Concerns

• Nocdurna can cause water retention, which may lead to hyponatremia (low sodium levels in the blood). This condition can be dangerous and may cause symptoms like nausea, headache, confusion, and seizures. It is important to follow your healthcare provider’s instructions on fluid intake to avoid this risk.
• People with impaired kidney function should use Nocdurna with caution. Kidney problems may affect how the body processes the medication, and dosage adjustments may be necessary.
• Desmopressin can affect blood pressure, so it should be used with caution in patients with cardiovascular conditions, including high blood pressure or heart disease.
• Common side effects include headaches, nausea, dizziness, and abdominal discomfort. If these symptoms persist or become severe, contact your healthcare provider.
• Nocdurna should only be used during pregnancy or breastfeeding if the potential benefit justifies the potential risk. Speak with a healthcare provider before using this medication in these circumstances.