Prempro (Conjugated estrogens / Medroxyprogesterone)

Prempro is called Premique in Europe.

Information about Prempro (Conjugated Estrogens / Medroxyprogesterone)

Prempro is a combination medication that contains conjugated estrogens (a mixture of estrogen hormones derived from the urine of pregnant mares) and medroxyprogesterone acetate (a synthetic form of progesterone). This combination is used primarily in hormone replacement therapy (HRT) to relieve menopausal symptoms and to prevent osteoporosis in postmenopausal women. Prempro is typically prescribed to women who still have their uterus to balance the effects of estrogen and reduce the risk of endometrial cancer.

Product Highlights

• Used to treat moderate to severe symptoms of menopause, including hot flashes, night sweats, vaginal dryness, and mood swings.
• Helps prevent bone loss and reduce the risk of fractures in postmenopausal women.
• Used in women with a uterus to provide estrogen replacement and prevent the risk of endometrial hyperplasia, which can be caused by estrogen alone.
• Used to treat conditions where the body has insufficient estrogen, such as in premature ovarian failure.

Key Ingredient

• Conjugated Estrogens
• Medroxyprogesterone Acetate

Key Benefits

• Helps alleviate hot flashes, night sweats, vaginal dryness, and other common menopausal symptoms.
• Lowers the risk of bone loss and fractures in postmenopausal women. 
• The progestin component helps protect the uterine lining from overgrowth caused by estrogen, thus reducing the risk of endometrial cancer in women with a uterus.
• Can help stabilize mood and reduce irritability and fatigue associated with menopause.
• Balances estrogen and progesterone levels to provide comprehensive HRT for women with a uterus.

Direction of Use

• Prempro is usually taken once daily, at the same time each day. It can be taken with or without food, according to the healthcare provider's instructions. 
• The prescribed dosage will vary depending on the individual’s needs and the condition being treated. Typically, it is taken as a combination therapy with both estrogen and progestin for a specified period, followed by a break or continued therapy depending on the doctor’s advice.
• For optimal benefit, Prempro should be taken consistently as prescribed to effectively manage symptoms and maintain hormonal balance.

Safety Concerns

• Estrogen therapy, including Prempro, may increase the risk of blood clots, deep vein thrombosis (DVT), pulmonary embolism (PE), and stroke, especially in women with other risk factors.
• Long-term use of combined estrogen and progestin therapy may increase the risk of breast cancer and endometrial cancer in some women.
• Estrogen therapy may increase the risk of heart disease and stroke, particularly in women who start therapy later in life or have preexisting cardiovascular conditions.
• Prempro may affect liver function, so regular monitoring may be necessary for those with liver conditions.
• Common side effects include breast tenderness, headaches, nausea, and mood swings.
• There may be an increased risk of depression or anxiety in some women using Prempro, so monitoring for mood changes is important.

Avoid Prempro (Conjugated Estrogens / Medroxyprogesterone) If

• Prempro should be avoided during pregnancy as it may harm the fetus. 
• Avoid use in women with a history of breast cancer, endometrial cancer, or other hormone-dependent cancers. 
• Prempro should not be used in women with unexplained vaginal bleeding, as it may indicate a serious underlying condition.
• Estrogen therapy may increase the risk of blood clots, stroke, or heart disease, and should be avoided by those with a history of such conditions.
• Women with severe liver disease should avoid using Prempro due to the potential for liver dysfunction.
• Do not use Prempro if allergic to any of its ingredients, including conjugated estrogens or medroxyprogesterone.