Vraylar goes by the trade name Reagila in Europe under the license of Recordati Pharmaceuticals.
Prescription Vraylar is used by adults in the treatment of bipolar depression and short term treatment of manic and mixed episodes associated with bipolar I disorder. An important part of treatment along with Vraylar is having a good support group around you, which includes talk therapy and monitoring symptoms throughout treatment. Although, patients with bipolar disorder, often have symptoms develop early in their life they can also get it later in life and often struggle with the disorder through their lifetime.
Although the exact mechanism by which Vraylar works is unkown, it works on seretonin and dopamine levels to moderate moods (ups and downs) associated with bipolar I disorder. Vraylar improves over symptoms (depression and mania), treats episodes called mixed episodes, and reduces condition severity overall.
Vraylar starts working gradually and differently for every patient. Talk to your physician about Vraylar treatment and keep a record or diary to share with your doctor and support team. Take Vraylar once per day, without regards to food (with or without food).
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Information about Vraylar (Cariprazine)
Vraylar is a medication that contains cariprazine, which is an atypical antipsychotic used to treat mental health conditions such as schizophrenia and bipolar disorder. Cariprazine works by balancing certain chemicals in the brain, particularly dopamine and serotonin, to help control mood, thoughts, and behavior. It is specifically classified as a dopamine D3 and D2 receptor partial agonist, which means it modulates the activity of dopamine receptors in the brain.
Product Highlights
Vraylar is used to treat schizophrenia in adults. It helps manage symptoms such as delusions, hallucinations, and disorganized thinking.
Vraylar is used to treat bipolar disorder in adults, specifically for acute manic or mixed episodes. It can also be used as a maintenance treatment to prevent episodes.
It is sometimes used in combination with other medications for the treatment of bipolar depression, though it is not typically the first-line treatment.
Key Ingredient
Cariprazine
Key Benefits
Vraylar helps reduce the severity of symptoms such as hallucinations, delusions, and disorganized thinking in schizophrenia.
Vraylar helps manage both acute manic and mixed episodes in bipolar disorder, which are characterized by extreme mood swings.
Cariprazine's unique pharmacological profile allows for longer-lasting effects, reducing the need for frequent dose adjustments.
Compared to other antipsychotic medications, Vraylar is associated with a lower incidence of movement disorders (e.g., tremors or stiffness), which are common with other antipsychotics.
Direction of Use
The usual starting dose for Vraylar in treating schizophrenia is 1.5 mg per day, which may be adjusted based on the patient's response. The recommended dose for bipolar mania is typically 3–6 mg per day.
Vraylar should be taken once a day, either with or without food.
It's important to take Vraylar at the same time each day to maintain steady levels of the medication in the body.
The medication comes in oral capsule form, which should be swallowed whole.
Starting Dose
Recommended Dose
Schizophrenia
1.5 mg/day
1.5 mg to 6 mg/day
Bipolar Mania
1.5 mg/day
3 mg to 6 mg/day
Doses greater than 6 mg daily do not provide significant additional benefits but may increase the risk of dose-related side effects.
Safety Concerns
Like other atypical antipsychotics, Vraylar may be associated with weight gain, increased blood sugar levels, and changes in cholesterol. Regular monitoring of weight, blood sugar, and cholesterol levels is recommended.
Though Vraylar generally causes fewer extrapyramidal symptoms (EPS) compared to other antipsychotics, side effects such as tremors, rigidity, or involuntary movements (tardive dyskinesia) may still occur in some individuals.
Some people may experience drowsiness, especially when first starting the medication. It is important to be cautious about activities that require full alertness, such as driving.
This rare but serious condition is characterized by fever, muscle rigidity, altered mental status, and autonomic dysfunction. If any of these symptoms arise, seek medical attention immediately.
Some individuals may experience a drop in blood pressure when standing up, which can lead to dizziness or fainting.
As with many antipsychotic medications, patients, especially young adults, may experience increased thoughts of suicide. Close monitoring is recommended during the early stages of treatment.
Avoid Vraylar (Cariprazine) If
You have a known allergy to cariprazine or any of the ingredients in Vraylar.
You have a history of severe cardiovascular problems, including heart disease or arrhythmias.
You have a **history of neuroleptic malignant syndrome (NMS), a potentially life-threatening condition caused by antipsychotic drugs.
You are pregnant or planning to become pregnant, unless the benefits outweigh the risks, as Vraylar is not recommended during pregnancy.
You are breastfeeding, as it is not known if Vraylar passes into breast milk and could harm the baby.
You have a history of movement disorders such as Parkinson’s disease, as Vraylar may worsen these conditions.
You are taking medications that can interact with Vraylar, such as CYP3A4 inhibitors or CYP3A4 inducers, as these can affect cariprazine’s metabolism.
