Zonalon cream (Doxepin)

Zonalon cream is called Xepin in Europe.

Information about Zonalon Cream (Doxepin)

Zonalon Cream is a topical medication containing Doxepin, which is a tricyclic antidepressant. When used in the cream form, Doxepin acts as a topical anti-pruritic (anti-itch) agent and is primarily prescribed to treat skin conditions causing itching or inflammation. It is typically used for conditions like atopic dermatitis or eczema and may provide relief from severe itching associated with these conditions.

Product Highlights

• Zonalon Cream is used to treat:
• A chronic inflammatory skin condition often associated with severe itching.
• Another skin condition that causes itching, irritation, and inflammation.
• General itching caused by various dermatological conditions.

Key Ingredient

• Doxepin

Key Benefits

• Doxepin works by reducing histamine activity on the skin, providing relief from itching.
• Helps in reducing inflammation associated with allergic skin conditions.
• Can be applied directly to affected areas, minimizing systemic side effects compared to oral medications.
• Since it's applied topically, it does not generally cause the sedative effects that oral Doxepin may cause.

Direction of Use

• Apply a thin layer of Zonalon cream to the affected areas of the skin 3–4 times daily or as directed by a healthcare provider.
• Do not apply the cream to broken or irritated skin, eyes, or mucous membranes (mouth, nose, etc.).
• Always wash hands after applying the cream to avoid accidental contact with the eyes or mucous membranes.

Safety Concerns

• Localized burning, stinging, or irritation at the application site can occur. In rare cases, allergic reactions may happen, which could include swelling, redness, or a rash.
• While minimal, systemic absorption is possible, especially if the cream is applied to large areas of skin or broken skin, leading to the possibility of side effects similar to oral Doxepin (sedation, drowsiness).
• Typically considered safe for use during pregnancy when prescribed by a healthcare provider, but should only be used if absolutely necessary.
• Should not be used simultaneously with other topical products that may increase the absorption of the medication or cause irritation.

Avoid Zonalon Cream (Doxepin) If

• You have a known hypersensitivity or allergy to Doxepin or any other components of the cream.
• You are pregnant or breastfeeding, unless your healthcare provider has recommended its use. 
• You have certain skin conditions that may prevent the proper absorption of the cream (e.g., broken or severely irritated skin).
• You are already taking oral Doxepin or other sedating antihistamines (for risk of excessive sedation).