Information about Dibenzyline (Phenoxybenzamine)
Dibenzyline, known generically as Phenoxybenzamine, is a non-selective alpha-adrenergic antagonist used primarily to manage hypertension associated with pheochromocytoma (a type of tumor that secretes excess adrenaline). It works by blocking the alpha-adrenergic receptors, leading to vasodilation and decreased blood pressure.
Product Highlights
- Phenoxybenzamine is primarily used for the treatment of hypertension related to pheochromocytoma, a rare tumor of the adrenal gland that produces excessive amounts of adrenaline and noradrenaline.
- It is used to control blood pressure in patients with pheochromocytoma before surgical removal of the tumor.
Key Ingredient
Key Benefits
- Phenoxybenzamine has a long duration of action due to its irreversible binding to alpha-adrenergic receptors.
- Effectively helps in controlling high blood pressure caused by pheochromocytoma.
- Reduces symptoms associated with pheochromocytoma, such as severe headaches, sweating, and palpitations.
Direction of Use
- The dosage of Phenoxybenzamine is individualized based on the patient’s condition. Typically, treatment starts with a low dose to minimize side effects and is gradually adjusted.
- Capsules should be swallowed whole with water. They are usually taken 1-2 times a day, preferably on an empty stomach.
Safety Concerns
- Common side effects include dizziness, drowsiness, nasal congestion, and hypotension (low blood pressure). More serious side effects might include syncope (fainting), tachycardia (rapid heartbeat), and severe hypotension.
- Regular monitoring of blood pressure and heart rate is recommended during treatment.
- Phenoxybenzamine may interact with other medications, such as antihypertensives and anesthetics, which can exacerbate hypotension.
Avoid Dibenzyline (Phenoxybenzamine) If
- You have a known allergy or hypersensitivity to Phenoxybenzamine or any of its components.
- Phenoxybenzamine should be used with caution in patients with severe liver disease due to potential metabolic concerns.
- It is generally advised to avoid use during pregnancy unless absolutely necessary and prescribed by a healthcare professional. There is limited information on the safety of Phenoxybenzamine during pregnancy.
- It should be used with caution in patients who have recently had a heart attack due to potential exacerbation of cardiovascular issues.
