Information about Wakix (Pitolisant)
Wakix (pitolisant) is a medication used primarily to treat narcolepsy, a chronic sleep disorder characterized by excessive daytime sleepiness and sudden sleep attacks. Pitolisant is a histamine H3 receptor antagonist and inverse agonist that increases histamine release in the brain. This results in enhanced wakefulness and improved attention.
Product Highlights
- It is used to treat excessive daytime sleepiness in adults with narcolepsy, either with or without cataplexy (sudden muscle weakness or paralysis).
- It can also be used off-label for other conditions related to impaired wakefulness, though this is less common.
Key Ingredient
Key Benefits
- Pitolisant helps people with narcolepsy stay awake and reduce the frequency of sleep attacks during the day.
- As a non-stimulant, it has a lower potential for abuse compared to other treatments for narcolepsy, such as amphetamines or other stimulants.
- Compared to traditional stimulants, Wakix generally has a more favorable side effect profile.
- While it promotes wakefulness, it does not cause the sedation that some other treatments might.
Direction of Use
- The usual starting dose for adults is 4.5 mg per day, taken once daily in the morning. The dose can be increased to a maximum of 18 mg per day depending on the patient’s response and tolerance.
- The tablet should be taken whole, with or without food.
- For best results, take Wakix at the same time each day to help establish a routine.
Safety Concerns
- Common side effects may include insomnia, headache, nausea, anxiety, and irritability.
- There have been reports of elevated heart rate or blood pressure in some patients.
- Some people may experience mood changes, agitation, or anxiety. Rarely, it can lead to more severe psychiatric symptoms like depression.
- Pitolisant is processed by the liver, so it should be used with caution in patients with liver impairment.
- Wakix can interact with other medications, especially those that influence liver enzymes, so it’s important to inform your doctor about all other medications you are taking.
Avoid Wakix (Pitolisant) If
- You are allergic to pitolisant or any of the ingredients in Wakix.
- You have a severe liver disorder, as Wakix is metabolized in the liver.
- You are taking monoamine oxidase inhibitors (MAOIs), as these can interact with pitolisant.
- You have severe cardiovascular problems such as uncontrolled high blood pressure or a history of heart disease, since Wakix can elevate heart rate and blood pressure.
- You have a history of severe psychiatric disorders like depression or anxiety, as Wakix can exacerbate certain mental health conditions.
