Information about Daraprim (Pyrimethamine)
Daraprim is a brand name for the medication pyrimethamine, which is an antiprotozoal drug. Pyrimethamine is primarily used to treat and prevent protozoal infections by inhibiting the folic acid synthesis required for the growth and replication of these parasites. It is commonly used in combination with other drugs to manage specific parasitic diseases.
Product Highlights
- Pyrimethamine is used in combination with sulfadiazine to treat toxoplasmosis, a parasitic infection caused by Toxoplasma gondii.
- It is used in combination with other antimalarial drugs, such as sulfadoxine, for the treatment and prevention of malaria.
- Used as part of a combination regimen for prophylaxis in patients with HIV/AIDS who are intolerant to sulfa drugs.
Key Ingredient
Key Benefits
- Provides targeted treatment for protozoal infections like toxoplasmosis and malaria.
- When used in combination with other medications, it enhances the effectiveness of treatment for complex infections.
- Useful in preventing PCP in high-risk populations, especially those with HIV/AIDS.
Direction of Use
- The typical dosage is 25 mg to 50 mg once daily or as directed by a healthcare provider.
- For specific infections, such as toxoplasmosis or malaria, the dosing schedule and duration will vary. Adhering closely to the prescribed regimen is crucial.
Safety Concerns
- Pyrimethamine can cause bone marrow suppression, leading to conditions like anemia, leukopenia, and thrombocytopenia.
- Regular monitoring of blood cell counts is recommended to detect any potential issues early.
- Potential for severe allergic reactions, including rash, fever, and anaphylaxis, although these are rare.
Avoid Daraprim (Pyrimethamine) If
- Avoid if there is a known allergy to pyrimethamine or any components of the formulation.
- Individuals with a history of significant bone marrow disorders or blood dyscrasias should avoid pyrimethamine or use it under close medical supervision.
- Use during pregnancy should be avoided unless absolutely necessary and prescribed by a healthcare provider, as it may pose risks to the fetus.
